Layer 6 Continuous Accommodating Untufted Pyramidal Cell (2)

Model Type:
Cell
Neurolex IDs: Neocortex Layer 6
Pyramidal Cell
Keywords: continuous accommodating for pyramidal cells,Layer 6,Untufted, pyramidal, rat, neocortex, somatosensory cortex
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000678
cADpyr231_L6_UTPC_186e8dd6aa_0_0.cell.nml
( view NeuroML )
NMLCH000102
Ca_HVA.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000678
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Accommodating Wide AP Multi-Spikers (awMS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -72.82 mV
Rheobase Current Interval (0.07874, 0.08057] nA
Threshold Current Interval (0.41016, 0.46875] nA
Bias Current (to -80.00 mV) -0.0304 nA
Testing Temperature 34.0 °C
Stability Interval [-2.8125, 15.0] nA
AP 1-2 Amplitude Drop 4.1486 mV
AP 1 Steady State Amplitude Change 2.9381 mV
AP 1 Amplitude 83.8336 mV
AP 1 Width at Half Height 0.8800 ms
AP 1 Width (Peak To Trough) 7.6900 ms
AP 1 Rate of Change Peak to Trough -11.7417 mV/ms
AP 1 AHP Depth 6.4598 mV
AP2 Amplitude 79.6850 mV
AP2 Width at Half Height 0.8800 ms
AP 2 Width (Peak to Trough) 12.6000 ms
AP 2 Rate of Change Peak to Trough -6.9818 mV/ms
AP 2 AHP Depth 8.2863 mV
AP 1-2 Amplitude Change Percent -4.9487 %
AP 1-2 Half Width Change Percent 0.0000 %
AP 1-2 Rate of Change Peak to Trough Percent Change -40.5378 %
AP 1-2 AHP Depth Percent Change 28.2757 %
Input Resistance 227.7948 MΩ
AP 1 Delay Mean 31.5800 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 75.5500 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 64.4650 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -50.0000 %
Steady State Accommodation Mean -50.0000 %
Accommodation Rate to Steady State -0.0774 %/ms
Accommodation at Steady State Mean -88.3204 %
Accommodation Rate Mean at Steady State 212.9761 ms
ISI CV 2.6060
ISI Median 257.7600 ms
ISI Burst Mean Change 93.2227 %
Spike Rate (Strong Stimulation) 8.0000 Hz
AP 1 Delay Mean (Strong Stimulation) 8.5000 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 26.7000 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 22.0600 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2039.7000 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 122.7984 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 4504.35 µm2
Number of Stems 10.0
Number of Bifurcations 32.0
Number of Branches 73.0
Overall Width 471.906 µm
Overall Height 1256.09 µm
Overall Depth 294.06 µm
Average Diameter 0.399355 µm
Total Length 9369.54 µm
Total Surface 10829.1 µm2
Total Volume 2448.6 µm3
Max Euclidean Distance 1101.3 µm
Max Path Distance 1184.02 µm
Max Branch Order 11.0
Average Contraction 0.958645
Total Fragmentation 3349.0
Partition Asymmetry 0.526488
Average Rall's Ratio 1.19136
Average Bifurcation Angle Local 66.4337 °
Average Bifurcation Angle Remote 61.4334 °
Fractal Dimension 1.00682
Complexity Summary
State Equations 1757
Optimal Time-Step 0.00769 ms
Relative Complexity 407.78 HH
Model Size
Sections 74
Compartments 474
State Equations 1757
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00769 ms
Optimal Time-Step Error 0.14 %
Optimal Time-Step Benchmark Run Time 407.78 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 1.14 %
Max. Stable Time-Step Benchmark Run Time 784.07 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 17124 Hz
CVODE Steps Per AP 328
CVODE Benchmark Run Time 420.97 HH
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