Layer 6 Continuous Accommodating Untufted Pyramidal Cell (1)

Model Type:
Cell
Neurolex IDs: Neocortex Layer 6
Pyramidal Cell
Keywords: continuous accommodating for pyramidal cells,Layer 6,Untufted, pyramidal, rat, neocortex, somatosensory cortex
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000677
cADpyr231_L6_UTPC_15731e5081_0_0.cell.nml
( view NeuroML )
NMLCH000102
Ca_HVA.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000677
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Accommodating Wide AP Multi-Spikers (awMS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -72.81 mV
Rheobase Current Interval (0.14740, 0.15060] nA
Threshold Current Interval (0.76172, 0.82031] nA
Bias Current (to -80.00 mV) -0.0534 nA
Testing Temperature 34.0 °C
Stability Interval [-5.0, 15.0] nA
AP 1-2 Amplitude Drop 5.2574 mV
AP 1 Steady State Amplitude Change 5.9412 mV
AP 1 Amplitude 78.0341 mV
AP 1 Width at Half Height 1.0200 ms
AP 1 Width (Peak To Trough) 18.8300 ms
AP 1 Rate of Change Peak to Trough -4.3285 mV/ms
AP 1 AHP Depth 3.4723 mV
AP2 Amplitude 72.7768 mV
AP2 Width at Half Height 1.0300 ms
AP 2 Width (Peak to Trough) 21.9900 ms
AP 2 Rate of Change Peak to Trough -3.6255 mV/ms
AP 2 AHP Depth 6.9475 mV
AP 1-2 Amplitude Change Percent -6.7373 %
AP 1-2 Half Width Change Percent 0.9804 %
AP 1-2 Rate of Change Peak to Trough Percent Change -16.2425 %
AP 1-2 AHP Depth Percent Change 100.0804 %
Input Resistance 128.9632 MΩ
AP 1 Delay Mean 25.6500 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 70.5600 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 68.4000 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -66.6667 %
Steady State Accommodation Mean -33.3333 %
Accommodation Rate to Steady State -0.0494 %/ms
Accommodation at Steady State Mean -88.0457 %
Accommodation Rate Mean at Steady State 196.4805 ms
ISI CV 2.6887
ISI Median 257.7300 ms
ISI Burst Mean Change 104.6092 %
Spike Rate (Strong Stimulation) 8.0000 Hz
AP 1 Delay Mean (Strong Stimulation) 7.5500 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 28.3500 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 24.7600 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2038.0700 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 126.8563 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 6192.62 µm2
Number of Stems 9.0
Number of Bifurcations 39.0
Number of Branches 86.0
Overall Width 299.719 µm
Overall Height 956.861 µm
Overall Depth 198.87 µm
Average Diameter 0.581349 µm
Total Length 8694.57 µm
Total Surface 16067.9 µm2
Total Volume 4947.73 µm3
Max Euclidean Distance 1032.12 µm
Max Path Distance 1112.42 µm
Max Branch Order 13.0
Average Contraction 0.931038
Total Fragmentation 7256.0
Partition Asymmetry 0.669132
Average Rall's Ratio 1.4182
Average Bifurcation Angle Local 67.0536 °
Average Bifurcation Angle Remote 61.7614 °
Fractal Dimension 1.01281
Complexity Summary
State Equations 1767
Optimal Time-Step 0.00774 ms
Relative Complexity 384.00 HH
Model Size
Sections 87
Compartments 439
State Equations 1767
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00774 ms
Optimal Time-Step Error 0.21 %
Optimal Time-Step Benchmark Run Time 384.00 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 0.51 %
Max. Stable Time-Step Benchmark Run Time 742.62 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 17270 Hz
CVODE Steps Per AP 360
CVODE Benchmark Run Time 407.74 HH
Website & Images Copyright NeuroML © 2022 For questions: Contact us Links: Search Test |  ModelDB WS