Layer 6 Continuous Accommodating Tufted Pyramidal Cell with apical dendrites terminating in layer 4 (3)

Model Type:
Cell
Neurolex IDs: Neocortex Layer 6
Pyramidal Cell
Keywords: continuous accommodating for pyramidal cells,Layer 6,Tufted, pyramidal, apical dendrites terminating in layer 4, rat, somatosensory cortex, neocortex, biophysical, continuous accommodating tufted pyramidal cell, Realistic Network, Neuron or other electrically excitable cell, Synapse, Spatio-temporal Activity Patterns, Detailed Neuronal Models
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000674
cADpyr231_L6_TPC_L4_184fd5677b_0_0.cell.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCH001436
Ca_HVA.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000674
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Accommodating Wide AP Multi-Spikers (awMS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -71.72 mV
Rheobase Current Interval (0.11444, 0.11673] nA
Threshold Current Interval (0.52734, 0.58594] nA
Bias Current (to -80.00 mV) -0.0522 nA
Testing Temperature 34.0 °C
Stability Interval [-3.75, 15.0] nA
AP 1-2 Amplitude Drop 6.1404 mV
AP 1 Steady State Amplitude Change 5.6683 mV
AP 1 Amplitude 77.0658 mV
AP 1 Width at Half Height 1.0400 ms
AP 1 Width (Peak To Trough) 16.1600 ms
AP 1 Rate of Change Peak to Trough -5.0272 mV/ms
AP 1 AHP Depth 4.1744 mV
AP2 Amplitude 70.9254 mV
AP2 Width at Half Height 1.0700 ms
AP 2 Width (Peak to Trough) 20.0300 ms
AP 2 Rate of Change Peak to Trough -3.9495 mV/ms
AP 2 AHP Depth 8.1827 mV
AP 1-2 Amplitude Change Percent -7.9678 %
AP 1-2 Half Width Change Percent 2.8846 %
AP 1-2 Rate of Change Peak to Trough Percent Change -21.4384 %
AP 1-2 AHP Depth Percent Change 96.0215 %
Input Resistance 155.1872 MΩ
AP 1 Delay Mean 23.5900 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 66.7300 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 67.0950 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -50.0000 %
Steady State Accommodation Mean -50.0000 %
Accommodation Rate to Steady State -0.0763 %/ms
Accommodation at Steady State Mean -88.3011 %
Accommodation Rate Mean at Steady State 205.2365 ms
ISI CV 2.6579
ISI Median 257.3700 ms
ISI Burst Mean Change 111.0570 %
Spike Rate (Strong Stimulation) 8.5000 Hz
AP 1 Delay Mean (Strong Stimulation) 6.7300 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 24.5500 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 22.6750 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2037.7000 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 124.1777 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 3935.8 µm2
Number of Stems 10.0
Number of Bifurcations 36.0
Number of Branches 81.0
Overall Width 627.136 µm
Overall Height 900.056 µm
Overall Depth 286.03 µm
Average Diameter 0.599116 µm
Total Length 8090.42 µm
Total Surface 15194.1 µm2
Total Volume 4161.78 µm3
Max Euclidean Distance 1059.09 µm
Max Path Distance 1285.97 µm
Max Branch Order 13.0
Average Contraction 0.930703
Total Fragmentation 6395.0
Partition Asymmetry 0.52166
Average Rall's Ratio 1.25043
Average Bifurcation Angle Local 67.4917 °
Average Bifurcation Angle Remote 68.198 °
Fractal Dimension 1.0141
Complexity Summary
Relative Complexity 450.23 HH
State Equations 1961
Optimal Time-Step 0.00803 ms
Model Size
Sections 82
Compartments 412
State Equations 1961
Variable Time-Step Complexity
CVODE Steady State Step Frequency 16955 Hz
CVODE Steps Per AP 263
CVODE Benchmark Run Time 450.23 HH
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