Layer 6 Continuous Accommodating Tufted Pyramidal Cell with apical dendrites terminating in layer 4 (1)

Model Type:
Cell
Neurolex IDs: Neocortex Layer 6
Pyramidal Cell
Keywords: continuous accommodating for pyramidal cells,Layer 6,Tufted, pyramidal, apical dendrites terminating in layer 4, rat, somatosensory cortex, neocortex
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000672
cADpyr231_L6_TPC_L4_0cb1e9aa6b_0_0.cell.nml
( view NeuroML )
NMLCH000102
Ca_HVA.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000672
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Accommodating Wide AP Multi-Spikers (awMS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -72.06 mV
Rheobase Current Interval (0.12589, 0.12817] nA
Threshold Current Interval (0.52734, 0.58594] nA
Bias Current (to -80.00 mV) -0.0535 nA
Testing Temperature 34.0 °C
Stability Interval [-4.0625, 15.0] nA
AP 1-2 Amplitude Drop 5.0937 mV
AP 1 Steady State Amplitude Change 4.5005 mV
AP 1 Amplitude 77.4558 mV
AP 1 Width at Half Height 1.0300 ms
AP 1 Width (Peak To Trough) 16.2600 ms
AP 1 Rate of Change Peak to Trough -5.0735 mV/ms
AP 1 AHP Depth 5.0389 mV
AP2 Amplitude 72.3621 mV
AP2 Width at Half Height 1.0500 ms
AP 2 Width (Peak to Trough) 19.5000 ms
AP 2 Rate of Change Peak to Trough -4.1141 mV/ms
AP 2 AHP Depth 7.8623 mV
AP 1-2 Amplitude Change Percent -6.5763 %
AP 1-2 Half Width Change Percent 1.9417 %
AP 1-2 Rate of Change Peak to Trough Percent Change -18.9103 %
AP 1-2 AHP Depth Percent Change 56.0300 %
Input Resistance 144.5290 MΩ
AP 1 Delay Mean 23.8300 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 67.8200 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 61.8800 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -50.0000 %
Steady State Accommodation Mean -75.0000 %
Accommodation Rate to Steady State N/A %/ms
Accommodation at Steady State Mean -87.0796 %
Accommodation Rate Mean at Steady State 213.7273 ms
ISI CV 2.6162
ISI Median 241.5300 ms
ISI Burst Mean Change 81.3367 %
Spike Rate (Strong Stimulation) 9.0000 Hz
AP 1 Delay Mean (Strong Stimulation) 6.6600 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 25.8100 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 22.6800 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2037.5700 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 76.7934 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 3935.8 µm2
Number of Stems 10.0
Number of Bifurcations 36.0
Number of Branches 81.0
Overall Width 481.972 µm
Overall Height 947.324 µm
Overall Depth 217.02 µm
Average Diameter 0.599838 µm
Total Length 8370.83 µm
Total Surface 15480.4 µm2
Total Volume 4177.77 µm3
Max Euclidean Distance 1000.87 µm
Max Path Distance 1121.23 µm
Max Branch Order 13.0
Average Contraction 0.929106
Total Fragmentation 6407.0
Partition Asymmetry 0.52166
Average Rall's Ratio 1.24652
Average Bifurcation Angle Local 69.188 °
Average Bifurcation Angle Remote 68.353 °
Fractal Dimension 1.01516
Complexity Summary
State Equations 1969
Optimal Time-Step 0.00769 ms
Relative Complexity 505.57 HH
Model Size
Sections 82
Compartments 420
State Equations 1969
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00769 ms
Optimal Time-Step Error 0.14 %
Optimal Time-Step Benchmark Run Time 505.57 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 1.20 %
Max. Stable Time-Step Benchmark Run Time 971.20 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 17022 Hz
CVODE Steps Per AP 199
CVODE Benchmark Run Time 485.79 HH
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