Layer 6 Continuous Accommodating Tufted Pyramidal Cell with apical dendrites terminating in layer 1 (5)

Model Type:
Cell
Neurolex IDs: Neocortex Layer 6
Pyramidal Cell
Keywords: continuous accommodating for pyramidal cells,Layer 6,Tufted, pyramidal, apical dendrites terminating in layer 1, rat, somatosensory cortex, neocortex
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000671
cADpyr231_L6_TPC_L1_f2d985e7ff_0_0.cell.nml
( view NeuroML )
NMLCH000102
Ca_HVA.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000671
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Accommodating Wide AP Multi-Spikers (awMS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -72.87 mV
Rheobase Current Interval (0.09567, 0.09819] nA
Threshold Current Interval (0.58594, 0.64453] nA
Bias Current (to -80.00 mV) -0.0360 nA
Testing Temperature 34.0 °C
Stability Interval [-3.75, 15.0] nA
AP 1-2 Amplitude Drop 4.6335 mV
AP 1 Steady State Amplitude Change 4.8107 mV
AP 1 Amplitude 79.7618 mV
AP 1 Width at Half Height 0.9100 ms
AP 1 Width (Peak To Trough) 20.6300 ms
AP 1 Rate of Change Peak to Trough -3.9696 mV/ms
AP 1 AHP Depth 2.1308 mV
AP2 Amplitude 75.1283 mV
AP2 Width at Half Height 0.9200 ms
AP 2 Width (Peak to Trough) 25.0300 ms
AP 2 Rate of Change Peak to Trough -3.2347 mV/ms
AP 2 AHP Depth 5.8367 mV
AP 1-2 Amplitude Change Percent -5.8092 %
AP 1-2 Half Width Change Percent 1.0989 %
AP 1-2 Rate of Change Peak to Trough Percent Change -18.5124 %
AP 1-2 AHP Depth Percent Change 173.9259 %
Input Resistance 189.6833 MΩ
AP 1 Delay Mean 30.5600 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 72.2300 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 63.0200 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -50.0000 %
Steady State Accommodation Mean -50.0000 %
Accommodation Rate to Steady State -0.0764 %/ms
Accommodation at Steady State Mean -89.2632 %
Accommodation Rate Mean at Steady State 200.0493 ms
ISI CV 2.6012
ISI Median 256.7000 ms
ISI Burst Mean Change 102.4718 %
Spike Rate (Strong Stimulation) 8.0000 Hz
AP 1 Delay Mean (Strong Stimulation) 9.3200 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 25.6900 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 20.9700 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2033.5200 ms
Frequency Filter Type Constant
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 4149.49 µm2
Number of Stems 7.0
Number of Bifurcations 40.0
Number of Branches 86.0
Overall Width 276.269 µm
Overall Height 951.737 µm
Overall Depth 247.35 µm
Average Diameter 0.570809 µm
Total Length 7297.52 µm
Total Surface 12569.3 µm2
Total Volume 2889.18 µm3
Max Euclidean Distance 793.894 µm
Max Path Distance 871.769 µm
Max Branch Order 11.0
Average Contraction 0.943382
Total Fragmentation 4568.0
Partition Asymmetry 0.474108
Average Rall's Ratio 2.26818
Average Bifurcation Angle Local 59.1766 °
Average Bifurcation Angle Remote 57.5167 °
Fractal Dimension 1.01109
Complexity Summary
State Equations 1417
Optimal Time-Step 0.00780 ms
Relative Complexity 332.65 HH
Model Size
Sections 86
Compartments 364
State Equations 1417
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00780 ms
Optimal Time-Step Error 0.31 %
Optimal Time-Step Benchmark Run Time 332.65 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 0.89 %
Max. Stable Time-Step Benchmark Run Time 648.21 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 17830 Hz
CVODE Steps Per AP 261
CVODE Benchmark Run Time 348.63 HH
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