Layer 6 Continuous Accommodating Tufted Pyramidal Cell with apical dendrites terminating in layer 1 (3)

Model Type:
Cell
Neurolex IDs: Neocortex Layer 6
Pyramidal Cell
Keywords: continuous accommodating for pyramidal cells,Layer 6,Tufted, pyramidal, apical dendrites terminating in layer 1, rat, somatosensory cortex, neocortex
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000669
cADpyr231_L6_TPC_L1_68efb03f39_0_0.cell.nml
( view NeuroML )
NMLCH000102
Ca_HVA.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000669
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Accommodating Wide AP Multi-Spikers (awMS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -72.34 mV
Rheobase Current Interval (0.21744, 0.22179] nA
Threshold Current Interval (1.05469, 1.11328] nA
Bias Current (to -80.00 mV) -0.0853 nA
Testing Temperature 34.0 °C
Stability Interval [-6.5625, 15.0] nA
AP 1-2 Amplitude Drop 4.1695 mV
AP 1 Steady State Amplitude Change 4.3960 mV
AP 1 Amplitude 72.0203 mV
AP 1 Width at Half Height 1.0000 ms
AP 1 Width (Peak To Trough) 13.9300 ms
AP 1 Rate of Change Peak to Trough -5.7539 mV/ms
AP 1 AHP Depth 8.1315 mV
AP2 Amplitude 67.8508 mV
AP2 Width at Half Height 1.0300 ms
AP 2 Width (Peak to Trough) 16.1700 ms
AP 2 Rate of Change Peak to Trough -4.8133 mV/ms
AP 2 AHP Depth 9.9811 mV
AP 1-2 Amplitude Change Percent -5.7894 %
AP 1-2 Half Width Change Percent 3.0000 %
AP 1-2 Rate of Change Peak to Trough Percent Change -16.3463 %
AP 1-2 AHP Depth Percent Change 22.7452 %
Input Resistance 86.0210 MΩ
AP 1 Delay Mean 23.9700 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 69.1000 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 57.5300 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -50.0000 %
Steady State Accommodation Mean -50.0000 %
Accommodation Rate to Steady State -0.0789 %/ms
Accommodation at Steady State Mean -82.8922 %
Accommodation Rate Mean at Steady State 244.0647 ms
ISI CV 2.8688
ISI Median 201.9700 ms
ISI Burst Mean Change 54.9524 %
Spike Rate (Strong Stimulation) 11.5000 Hz
AP 1 Delay Mean (Strong Stimulation) 7.0200 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 26.2900 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 22.4850 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2039.4100 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 119.0867 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 5617.76 µm2
Number of Stems 11.0
Number of Bifurcations 43.0
Number of Branches 96.0
Overall Width 414.386 µm
Overall Height 803.103 µm
Overall Depth 306.78 µm
Average Diameter 0.853336 µm
Total Length 9681.25 µm
Total Surface 26002.0 µm2
Total Volume 7161.06 µm3
Max Euclidean Distance 835.947 µm
Max Path Distance 920.947 µm
Max Branch Order 18.0
Average Contraction 0.915233
Total Fragmentation 7267.0
Partition Asymmetry 0.521526
Average Rall's Ratio 3.15562
Average Bifurcation Angle Local 73.6852 °
Average Bifurcation Angle Remote 60.9324 °
Fractal Dimension 1.01521
Complexity Summary
State Equations 2395
Optimal Time-Step 0.00762 ms
Relative Complexity 596.45 HH
Model Size
Sections 97
Compartments 493
State Equations 2395
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00762 ms
Optimal Time-Step Error 0.15 %
Optimal Time-Step Benchmark Run Time 596.45 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 0.48 %
Max. Stable Time-Step Benchmark Run Time 1136.23 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 17715 Hz
CVODE Steps Per AP 115
CVODE Benchmark Run Time 563.99 HH
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