Layer 6 Continuous Accommodating Tufted Pyramidal Cell with apical dendrites terminating in layer 1 (2)

Model Type:
Cell
Neurolex IDs: Neocortex Layer 6
Pyramidal Cell
Keywords: continuous accommodating for pyramidal cells,Layer 6,Tufted, pyramidal, apical dendrites terminating in layer 1, rat, somatosensory cortex, neocortex
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000668
cADpyr231_L6_TPC_L1_44f2206f70_0_0.cell.nml
( view NeuroML )
NMLCH000102
Ca_HVA.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000668
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Accommodating Wide AP Multi-Spikers (awMS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -72.03 mV
Rheobase Current Interval (0.18265, 0.18585] nA
Threshold Current Interval (0.76172, 0.82031] nA
Bias Current (to -80.00 mV) -0.0716 nA
Testing Temperature 34.0 °C
Stability Interval [-5.0, 15.0] nA
AP 1-2 Amplitude Drop 4.7631 mV
AP 1 Steady State Amplitude Change 4.8202 mV
AP 1 Amplitude 84.4952 mV
AP 1 Width at Half Height 0.8700 ms
AP 1 Width (Peak To Trough) 13.8600 ms
AP 1 Rate of Change Peak to Trough -6.5597 mV/ms
AP 1 AHP Depth 6.4227 mV
AP2 Amplitude 79.7321 mV
AP2 Width at Half Height 0.8600 ms
AP 2 Width (Peak to Trough) 15.0500 ms
AP 2 Rate of Change Peak to Trough -5.8623 mV/ms
AP 2 AHP Depth 8.4954 mV
AP 1-2 Amplitude Change Percent -5.6371 %
AP 1-2 Half Width Change Percent -1.1494 %
AP 1-2 Rate of Change Peak to Trough Percent Change -10.6321 %
AP 1-2 AHP Depth Percent Change 32.2713 %
Input Resistance 106.1595 MΩ
AP 1 Delay Mean 20.5100 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 61.7300 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 53.0900 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -50.0000 %
Steady State Accommodation Mean -50.0000 %
Accommodation Rate to Steady State -0.0901 %/ms
Accommodation at Steady State Mean -88.8230 %
Accommodation Rate Mean at Steady State 193.2336 ms
ISI CV 2.6556
ISI Median 233.4150 ms
ISI Burst Mean Change 57.5934 %
Spike Rate (Strong Stimulation) 9.0000 Hz
AP 1 Delay Mean (Strong Stimulation) 5.9600 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 26.5100 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 22.7850 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2022.0900 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 69.5340 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 9748.01 µm2
Number of Stems 7.0
Number of Bifurcations 63.0
Number of Branches 132.0
Overall Width 354.009 µm
Overall Height 1164.36 µm
Overall Depth 247.37 µm
Average Diameter 0.626456 µm
Total Length 10172.1 µm
Total Surface 19529.5 µm2
Total Volume 7492.04 µm3
Max Euclidean Distance 1232.24 µm
Max Path Distance 1346.82 µm
Max Branch Order 26.0
Average Contraction 0.948544
Total Fragmentation 4821.0
Partition Asymmetry 0.550487
Average Rall's Ratio 1.061
Average Bifurcation Angle Local 59.9954 °
Average Bifurcation Angle Remote 59.5265 °
Fractal Dimension 1.01234
Complexity Summary
State Equations 2409
Optimal Time-Step 0.00756 ms
Relative Complexity 587.09 HH
Model Size
Sections 134
Compartments 510
State Equations 2409
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00756 ms
Optimal Time-Step Error 0.17 %
Optimal Time-Step Benchmark Run Time 587.09 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 1.04 %
Max. Stable Time-Step Benchmark Run Time 1108.76 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 16218 Hz
CVODE Steps Per AP 399
CVODE Benchmark Run Time 589.51 HH
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