Layer 6 Continuous Accommodating Pyramidal Cell with inverted apical-like dendrites (4)

Model Type:
Cell
Neurolex IDs: Neocortex Layer 6
Pyramidal Cell
Keywords: continuous accommodating for pyramidal cells,Layer 6,Pyramidal, inverted apical-like dendrites, rat, somatosensory cortex, neocortex
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000665
cADpyr231_L6_IPC_c56c0e0779_0_0.cell.nml
( view NeuroML )
NMLCH000102
Ca_HVA.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000665
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Accommodating Wide AP Multi-Spikers (awMS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -72.59 mV
Rheobase Current Interval (0.11673, 0.11902] nA
Threshold Current Interval (0.52734, 0.58594] nA
Bias Current (to -80.00 mV) -0.0447 nA
Testing Temperature 34.0 °C
Stability Interval [-4.0625, 15.0] nA
AP 1-2 Amplitude Drop 5.4251 mV
AP 1 Steady State Amplitude Change 4.4220 mV
AP 1 Amplitude 79.1468 mV
AP 1 Width at Half Height 0.9400 ms
AP 1 Width (Peak To Trough) 17.0500 ms
AP 1 Rate of Change Peak to Trough -4.9183 mV/ms
AP 1 AHP Depth 4.7102 mV
AP2 Amplitude 73.7218 mV
AP2 Width at Half Height 0.9600 ms
AP 2 Width (Peak to Trough) 19.2200 ms
AP 2 Rate of Change Peak to Trough -4.2545 mV/ms
AP 2 AHP Depth 8.0497 mV
AP 1-2 Amplitude Change Percent -6.8544 %
AP 1-2 Half Width Change Percent 2.1277 %
AP 1-2 Rate of Change Peak to Trough Percent Change -13.4966 %
AP 1-2 AHP Depth Percent Change 70.8980 %
Input Resistance 158.3592 MΩ
AP 1 Delay Mean 26.1900 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 71.5600 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 59.3550 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -75.0000 %
Steady State Accommodation Mean -50.0000 %
Accommodation Rate to Steady State -0.0976 %/ms
Accommodation at Steady State Mean -85.2412 %
Accommodation Rate Mean at Steady State 224.0693 ms
ISI CV 2.7424
ISI Median 222.1500 ms
ISI Burst Mean Change 61.6487 %
Spike Rate (Strong Stimulation) 9.5000 Hz
AP 1 Delay Mean (Strong Stimulation) 7.6600 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 28.1800 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 23.0300 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2025.7800 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 76.6655 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 3611.14 µm2
Number of Stems 7.0
Number of Bifurcations 39.0
Number of Branches 84.0
Overall Width 395.953 µm
Overall Height 643.784 µm
Overall Depth 262.53 µm
Average Diameter 0.618587 µm
Total Length 6487.26 µm
Total Surface 11948.8 µm2
Total Volume 3493.03 µm3
Max Euclidean Distance 552.13 µm
Max Path Distance 716.527 µm
Max Branch Order 9.0
Average Contraction 0.941648
Total Fragmentation 4515.0
Partition Asymmetry 0.431136
Average Rall's Ratio 1.43409
Average Bifurcation Angle Local 62.19 °
Average Bifurcation Angle Remote 66.918 °
Fractal Dimension 1.0123
Complexity Summary
State Equations 1339
Optimal Time-Step 0.00764 ms
Relative Complexity 317.58 HH
Model Size
Sections 85
Compartments 329
State Equations 1339
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00764 ms
Optimal Time-Step Error 0.12 %
Optimal Time-Step Benchmark Run Time 317.58 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 1.08 %
Max. Stable Time-Step Benchmark Run Time 606.27 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 16596 Hz
CVODE Steps Per AP 233
CVODE Benchmark Run Time 301.85 HH
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