Layer 6 Continuous Accommodating Pyramidal Cell with inverted apical-like dendrites (3)

Model Type:
Cell
Neurolex IDs: Neocortex Layer 6
Pyramidal Cell
Keywords: continuous accommodating for pyramidal cells,Layer 6,Pyramidal, inverted apical-like dendrites, rat, somatosensory cortex, neocortex
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000664
cADpyr231_L6_IPC_8d0f3a7d2e_0_0.cell.nml
( view NeuroML )
NMLCH000102
Ca_HVA.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000664
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Accommodating Wide AP Multi-Spikers (awMS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -72.55 mV
Rheobase Current Interval (0.11215, 0.11444] nA
Threshold Current Interval (0.52734, 0.58594] nA
Bias Current (to -80.00 mV) -0.0432 nA
Testing Temperature 34.0 °C
Stability Interval [-4.0625, 15.0] nA
AP 1-2 Amplitude Drop 5.3061 mV
AP 1 Steady State Amplitude Change 4.5223 mV
AP 1 Amplitude 77.6349 mV
AP 1 Width at Half Height 0.9700 ms
AP 1 Width (Peak To Trough) 18.0300 ms
AP 1 Rate of Change Peak to Trough -4.5616 mV/ms
AP 1 AHP Depth 4.6098 mV
AP2 Amplitude 72.3288 mV
AP2 Width at Half Height 0.9900 ms
AP 2 Width (Peak to Trough) 21.4300 ms
AP 2 Rate of Change Peak to Trough -3.7415 mV/ms
AP 2 AHP Depth 7.8525 mV
AP 1-2 Amplitude Change Percent -6.8347 %
AP 1-2 Half Width Change Percent 2.0619 %
AP 1-2 Rate of Change Peak to Trough Percent Change -17.9765 %
AP 1-2 AHP Depth Percent Change 70.3424 %
Input Resistance 164.7589 MΩ
AP 1 Delay Mean 25.9100 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 71.1600 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 64.0350 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -50.0000 %
Steady State Accommodation Mean -75.0000 %
Accommodation Rate to Steady State N/A %/ms
Accommodation at Steady State Mean -86.6041 %
Accommodation Rate Mean at Steady State 210.4946 ms
ISI CV 2.6586
ISI Median 241.8800 ms
ISI Burst Mean Change 83.0276 %
Spike Rate (Strong Stimulation) 9.0000 Hz
AP 1 Delay Mean (Strong Stimulation) 7.6800 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 28.2000 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 23.8600 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2022.5000 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 91.4320 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 3611.14 µm2
Number of Stems 7.0
Number of Bifurcations 39.0
Number of Branches 84.0
Overall Width 364.545 µm
Overall Height 612.747 µm
Overall Depth 209.85 µm
Average Diameter 0.618842 µm
Total Length 6066.13 µm
Total Surface 11384.3 µm2
Total Volume 3397.4 µm3
Max Euclidean Distance 521.993 µm
Max Path Distance 653.824 µm
Max Branch Order 9.0
Average Contraction 0.941415
Total Fragmentation 4511.0
Partition Asymmetry 0.431136
Average Rall's Ratio 1.43409
Average Bifurcation Angle Local 63.6842 °
Average Bifurcation Angle Remote 68.0228 °
Fractal Dimension 1.01247
Complexity Summary
State Equations 1275
Optimal Time-Step 0.00762 ms
Relative Complexity 307.70 HH
Model Size
Sections 85
Compartments 313
State Equations 1275
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00762 ms
Optimal Time-Step Error 0.20 %
Optimal Time-Step Benchmark Run Time 307.70 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 1.44 %
Max. Stable Time-Step Benchmark Run Time 585.92 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 15585 Hz
CVODE Steps Per AP 368
CVODE Benchmark Run Time 296.94 HH
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