Layer 6 Continuous Accommodating Pyramidal Cell with inverted apical-like dendrites (2)

Model Type:
Cell
Neurolex IDs: Neocortex Layer 6
Pyramidal Cell
Keywords: continuous accommodating for pyramidal cells,Layer 6,Pyramidal, inverted apical-like dendrites, rat, somatosensory cortex, neocortex
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000663
cADpyr231_L6_IPC_80ec904753_0_0.cell.nml
( view NeuroML )
NMLCH000102
Ca_HVA.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000663
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Accommodating Wide AP Multi-Spikers (awMS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -72.29 mV
Rheobase Current Interval (0.08331, 0.08492] nA
Threshold Current Interval (0.35156, 0.41016] nA
Bias Current (to -80.00 mV) -0.0354 nA
Testing Temperature 34.0 °C
Stability Interval [-2.1875, 15.0] nA
AP 1-2 Amplitude Drop 4.3876 mV
AP 1 Steady State Amplitude Change 3.8517 mV
AP 1 Amplitude 87.3932 mV
AP 1 Width at Half Height 0.8300 ms
AP 1 Width (Peak To Trough) 4.8400 ms
AP 1 Rate of Change Peak to Trough -19.1749 mV/ms
AP 1 AHP Depth 5.4132 mV
AP2 Amplitude 83.0055 mV
AP2 Width at Half Height 0.8200 ms
AP 2 Width (Peak to Trough) 5.4700 ms
AP 2 Rate of Change Peak to Trough -16.4955 mV/ms
AP 2 AHP Depth 7.2250 mV
AP 1-2 Amplitude Change Percent -5.0206 %
AP 1-2 Half Width Change Percent -1.2048 %
AP 1-2 Rate of Change Peak to Trough Percent Change -13.9733 %
AP 1-2 AHP Depth Percent Change 33.4684 %
Input Resistance 217.1259 MΩ
AP 1 Delay Mean 24.1300 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 62.7500 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 50.9450 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -50.0000 %
Steady State Accommodation Mean -75.0000 %
Accommodation Rate to Steady State N/A %/ms
Accommodation at Steady State Mean -90.0356 %
Accommodation Rate Mean at Steady State 203.8293 ms
ISI CV 2.4304
ISI Median 238.6900 ms
ISI Burst Mean Change 63.8270 %
Spike Rate (Strong Stimulation) 8.5000 Hz
AP 1 Delay Mean (Strong Stimulation) 6.0100 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 23.4900 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 19.4300 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2041.4000 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 122.3371 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 4917.85 µm2
Number of Stems 8.0
Number of Bifurcations 45.0
Number of Branches 97.0
Overall Width 473.06 µm
Overall Height 1000.8 µm
Overall Depth 394.61 µm
Average Diameter 0.419646 µm
Total Length 10640.6 µm
Total Surface 12093.7 µm2
Total Volume 2696.24 µm3
Max Euclidean Distance 964.299 µm
Max Path Distance 1067.15 µm
Max Branch Order 15.0
Average Contraction 0.940501
Total Fragmentation 4429.0
Partition Asymmetry 0.583189
Average Rall's Ratio 1.46667
Average Bifurcation Angle Local 68.6723 °
Average Bifurcation Angle Remote 71.5117 °
Fractal Dimension 1.01118
Complexity Summary
State Equations 2553
Optimal Time-Step 0.00769 ms
Relative Complexity 627.77 HH
Model Size
Sections 98
Compartments 540
State Equations 2553
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00769 ms
Optimal Time-Step Error 0.23 %
Optimal Time-Step Benchmark Run Time 627.77 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 0.89 %
Max. Stable Time-Step Benchmark Run Time 1205.87 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 17645 Hz
CVODE Steps Per AP 426
CVODE Benchmark Run Time 695.05 HH
Website & Images Copyright NeuroML © 2019 For questions: Contact us Links: Search Test |  ModelDB WS