Layer 6 Continuous Accommodating Pyramidal Cell with inverted apical-like dendrites (1)

Model Type:
Cell
Neurolex IDs: Neocortex Layer 6
Pyramidal Cell
Keywords: continuous accommodating for pyramidal cells,Layer 6,Pyramidal, inverted apical-like dendrites, rat, somatosensory cortex, neocortex
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000662
cADpyr231_L6_IPC_5ada6448ea_0_0.cell.nml
( view NeuroML )
NMLCH000102
Ca_HVA.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000662
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Accommodating Wide AP Multi-Spikers (awMS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -72.43 mV
Rheobase Current Interval (0.08331, 0.08492] nA
Threshold Current Interval (0.35156, 0.41016] nA
Bias Current (to -80.00 mV) -0.0319 nA
Testing Temperature 34.0 °C
Stability Interval [-2.1875, 15.0] nA
AP 1-2 Amplitude Drop 5.1194 mV
AP 1 Steady State Amplitude Change 6.7809 mV
AP 1 Amplitude 85.6519 mV
AP 1 Width at Half Height 0.8500 ms
AP 1 Width (Peak To Trough) 6.4200 ms
AP 1 Rate of Change Peak to Trough -14.1249 mV/ms
AP 1 AHP Depth 5.0300 mV
AP2 Amplitude 80.5325 mV
AP2 Width at Half Height 0.8400 ms
AP 2 Width (Peak to Trough) 9.9600 ms
AP 2 Rate of Change Peak to Trough -8.8021 mV/ms
AP 2 AHP Depth 7.1363 mV
AP 1-2 Amplitude Change Percent -5.9770 %
AP 1-2 Half Width Change Percent -1.1765 %
AP 1-2 Rate of Change Peak to Trough Percent Change -37.6839 %
AP 1-2 AHP Depth Percent Change 41.8758 %
Input Resistance 227.5479 MΩ
AP 1 Delay Mean 21.1200 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 57.0800 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 46.3100 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -75.0000 %
Steady State Accommodation Mean -50.0000 %
Accommodation Rate to Steady State -0.0962 %/ms
Accommodation at Steady State Mean -90.5378 %
Accommodation Rate Mean at Steady State 179.3035 ms
ISI CV 2.5594
ISI Median 221.0750 ms
ISI Burst Mean Change 57.5640 %
Spike Rate (Strong Stimulation) 8.5000 Hz
AP 1 Delay Mean (Strong Stimulation) 5.4700 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 22.5700 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 19.4200 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2026.6700 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 118.1205 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 3756.19 µm2
Number of Stems 6.0
Number of Bifurcations 21.0
Number of Branches 47.0
Overall Width 271.284 µm
Overall Height 672.496 µm
Overall Depth 307.96 µm
Average Diameter 0.548197 µm
Total Length 4960.02 µm
Total Surface 9067.54 µm2
Total Volume 2862.57 µm3
Max Euclidean Distance 574.559 µm
Max Path Distance 645.546 µm
Max Branch Order 12.0
Average Contraction 0.919887
Total Fragmentation 4005.0
Partition Asymmetry 0.607937
Average Rall's Ratio 1.335
Average Bifurcation Angle Local 73.8443 °
Average Bifurcation Angle Remote 65.2649 °
Fractal Dimension 1.01819
Complexity Summary
State Equations 1189
Optimal Time-Step 0.00795 ms
Relative Complexity 275.36 HH
Model Size
Sections 48
Compartments 250
State Equations 1189
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00795 ms
Optimal Time-Step Error 0.07 %
Optimal Time-Step Benchmark Run Time 275.36 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 1.35 %
Max. Stable Time-Step Benchmark Run Time 546.81 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 16864 Hz
CVODE Steps Per AP 442
CVODE Benchmark Run Time 306.18 HH
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