Layer 6 Continuous Accommodating Pyramidal Cell with bipolar apical-like dendrites (3)

Model Type:
Cell
Neurolex IDs: Neocortex Layer 6
Pyramidal Cell
Keywords: continuous accommodating for pyramidal cells,Layer 6,Pyramidal, bipolar apical-like dendrites, rat, somatosensory cortex, neocortex
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000659
cADpyr231_L6_BPC_2f96fbbd13_0_0.cell.nml
( view NeuroML )
NMLCH000102
Ca_HVA.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000659
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Accommodating Wide AP Multi-Spikers (awMS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -73.15 mV
Rheobase Current Interval (0.16479, 0.16846] nA
Threshold Current Interval (0.87891, 0.93750] nA
Bias Current (to -80.00 mV) -0.0515 nA
Testing Temperature 34.0 °C
Stability Interval [-5.625, 15.0] nA
AP 1-2 Amplitude Drop 4.0537 mV
AP 1 Steady State Amplitude Change 4.5472 mV
AP 1 Amplitude 82.1260 mV
AP 1 Width at Half Height 0.9000 ms
AP 1 Width (Peak To Trough) 12.3600 ms
AP 1 Rate of Change Peak to Trough -7.3247 mV/ms
AP 1 AHP Depth 8.4070 mV
AP2 Amplitude 78.0723 mV
AP2 Width at Half Height 0.9000 ms
AP 2 Width (Peak to Trough) 14.1900 ms
AP 2 Rate of Change Peak to Trough -6.2038 mV/ms
AP 2 AHP Depth 9.9591 mV
AP 1-2 Amplitude Change Percent -4.9359 %
AP 1-2 Half Width Change Percent 0.0000 %
AP 1-2 Rate of Change Peak to Trough Percent Change -15.3032 %
AP 1-2 AHP Depth Percent Change 18.4621 %
Input Resistance 121.3808 MΩ
AP 1 Delay Mean 25.4400 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 70.2500 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 59.5100 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -50.0000 %
Steady State Accommodation Mean -75.0000 %
Accommodation Rate to Steady State N/A %/ms
Accommodation at Steady State Mean -87.6711 %
Accommodation Rate Mean at Steady State 203.0217 ms
ISI CV 2.5853
ISI Median 241.8300 ms
ISI Burst Mean Change 65.6104 %
Spike Rate (Strong Stimulation) 8.5000 Hz
AP 1 Delay Mean (Strong Stimulation) 8.2800 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 29.7400 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 24.7250 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2025.3500 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 112.8737 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 10046.9 µm2
Number of Stems 7.0
Number of Bifurcations 56.0
Number of Branches 118.0
Overall Width 337.193 µm
Overall Height 613.252 µm
Overall Depth 325.58 µm
Average Diameter 0.685762 µm
Total Length 7655.56 µm
Total Surface 14258.1 µm2
Total Volume 5203.73 µm3
Max Euclidean Distance 502.509 µm
Max Path Distance 530.467 µm
Max Branch Order 11.0
Average Contraction 0.970846
Total Fragmentation 2876.0
Partition Asymmetry 0.431983
Average Rall's Ratio 1.7545
Average Bifurcation Angle Local 67.8621 °
Average Bifurcation Angle Remote 64.3611 °
Fractal Dimension 1.00535
Complexity Summary
State Equations 1601
Optimal Time-Step 0.00784 ms
Relative Complexity 351.83 HH
Model Size
Sections 118
Compartments 394
State Equations 1601
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00784 ms
Optimal Time-Step Error 0.13 %
Optimal Time-Step Benchmark Run Time 351.83 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 0.79 %
Max. Stable Time-Step Benchmark Run Time 689.58 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 13958 Hz
CVODE Steps Per AP 512
CVODE Benchmark Run Time 346.16 HH
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