Layer 6 Continuous Accommodating Pyramidal Cell with bipolar apical-like dendrites (1)

Model Type:
Cell
Neurolex IDs: Neocortex Layer 6
Pyramidal Cell
Keywords: continuous accommodating for pyramidal cells,Layer 6,Pyramidal, bipolar apical-like dendrites, rat, somatosensory cortex, neocortex
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000657
cADpyr231_L6_BPC_05f7073f5f_0_0.cell.nml
( view NeuroML )
NMLCH000102
Ca_HVA.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000657
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Accommodating Wide AP Multi-Spikers (awMS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -73.10 mV
Rheobase Current Interval (0.17303, 0.17715] nA
Threshold Current Interval (0.99609, 1.05469] nA
Bias Current (to -80.00 mV) -0.0509 nA
Testing Temperature 34.0 °C
Stability Interval [-5.625, 15.0] nA
AP 1-2 Amplitude Drop 4.4600 mV
AP 1 Steady State Amplitude Change 8.9666 mV
AP 1 Amplitude 78.8377 mV
AP 1 Width at Half Height 0.9700 ms
AP 1 Width (Peak To Trough) 13.0700 ms
AP 1 Rate of Change Peak to Trough -6.5768 mV/ms
AP 1 AHP Depth 7.1207 mV
AP2 Amplitude 74.3777 mV
AP2 Width at Half Height 0.9800 ms
AP 2 Width (Peak to Trough) 15.8700 ms
AP 2 Rate of Change Peak to Trough -5.2603 mV/ms
AP 2 AHP Depth 9.1026 mV
AP 1-2 Amplitude Change Percent -5.6572 %
AP 1-2 Half Width Change Percent 1.0309 %
AP 1-2 Rate of Change Peak to Trough Percent Change -20.0176 %
AP 1-2 AHP Depth Percent Change 27.8339 %
Input Resistance 121.8566 MΩ
AP 1 Delay Mean 22.3900 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 64.5900 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 56.3750 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -66.6667 %
Steady State Accommodation Mean -66.6667 %
Accommodation Rate to Steady State N/A %/ms
Accommodation at Steady State Mean -92.6258 %
Accommodation Rate Mean at Steady State 161.4091 ms
ISI CV 2.3023
ISI Median 267.0750 ms
ISI Burst Mean Change 67.1801 %
Spike Rate (Strong Stimulation) 8.0000 Hz
AP 1 Delay Mean (Strong Stimulation) 7.5000 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 27.7700 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 23.7800 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2075.7400 ms
Frequency Filter Type Band-Pass
Frequency Filter Pass Above 40.0076 Hz
Frequency Filter Pass Below 128.1028 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 10046.9 µm2
Number of Stems 7.0
Number of Bifurcations 56.0
Number of Branches 118.0
Overall Width 325.095 µm
Overall Height 602.968 µm
Overall Depth 287.46 µm
Average Diameter 0.686275 µm
Total Length 7499.98 µm
Total Surface 14059.3 µm2
Total Volume 5164.04 µm3
Max Euclidean Distance 478.006 µm
Max Path Distance 504.298 µm
Max Branch Order 11.0
Average Contraction 0.970726
Total Fragmentation 2875.0
Partition Asymmetry 0.431983
Average Rall's Ratio 1.7545
Average Bifurcation Angle Local 66.8754 °
Average Bifurcation Angle Remote 62.9907 °
Fractal Dimension 1.00524
Complexity Summary
State Equations 1589
Optimal Time-Step 0.00779 ms
Relative Complexity 354.00 HH
Model Size
Sections 118
Compartments 384
State Equations 1589
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00779 ms
Optimal Time-Step Error 0.31 %
Optimal Time-Step Benchmark Run Time 354.00 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 1.70 %
Max. Stable Time-Step Benchmark Run Time 689.31 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 16217 Hz
CVODE Steps Per AP 314
CVODE Benchmark Run Time 351.09 HH
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