Layer 4 Continuous Accommodating Spiny Stellate Cell (4)

Model Type:
Cell
Neurolex IDs: Neocortex Layer 4
Spiny Stellate Cell
Keywords: continuous accommodating for pyramidal cells,Layer 4,excitatory, neocortex, rat, somatosensory cortex, spiny, stellate
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000655
cADpyr230_L4_SS_a5ca6392b3_0_0.cell.nml
( view NeuroML )
NMLCH000102
Ca_HVA.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000655
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Accommodating Wide AP Multi-Spikers (awMS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -73.38 mV
Rheobase Current Interval (0.09567, 0.09819] nA
Threshold Current Interval (0.58594, 0.64453] nA
Bias Current (to -80.00 mV) -0.0409 nA
Testing Temperature 34.0 °C
Stability Interval [-4.6875, 15.0] nA
AP 1-2 Amplitude Drop 1.5207 mV
AP 1 Steady State Amplitude Change 0.7999 mV
AP 1 Amplitude 93.1235 mV
AP 1 Width at Half Height 0.6600 ms
AP 1 Width (Peak To Trough) 2.6300 ms
AP 1 Rate of Change Peak to Trough -39.1353 mV/ms
AP 1 AHP Depth 9.8024 mV
AP2 Amplitude 91.6028 mV
AP2 Width at Half Height 0.6500 ms
AP 2 Width (Peak to Trough) 2.7600 ms
AP 2 Rate of Change Peak to Trough -36.9671 mV/ms
AP 2 AHP Depth 10.4265 mV
AP 1-2 Amplitude Change Percent -1.6330 %
AP 1-2 Half Width Change Percent -1.5152 %
AP 1-2 Rate of Change Peak to Trough Percent Change -5.5403 %
AP 1-2 AHP Depth Percent Change 6.3661 %
Input Resistance 156.7115 MΩ
AP 1 Delay Mean 33.0500 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 91.6300 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 105.4700 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -66.6667 %
Steady State Accommodation Mean -66.6667 %
Accommodation Rate to Steady State N/A %/ms
Accommodation at Steady State Mean -80.2688 %
Accommodation Rate Mean at Steady State 217.2388 ms
ISI CV 3.0511
ISI Median 270.2400 ms
ISI Burst Mean Change 160.0888 %
Spike Rate (Strong Stimulation) 7.5000 Hz
AP 1 Delay Mean (Strong Stimulation) 11.0300 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 38.1100 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 32.9050 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2036.1300 ms
Frequency Filter Type Band-Pass
Frequency Filter Pass Above 34.5072 Hz
Frequency Filter Pass Below 78.5929 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 9349.08 µm2
Number of Stems 7.0
Number of Bifurcations 18.0
Number of Branches 42.0
Overall Width 392.975 µm
Overall Height 438.755 µm
Overall Depth 233.04 µm
Average Diameter 0.975715 µm
Total Length 4506.79 µm
Total Surface 11475.5 µm2
Total Volume 5056.9 µm3
Max Euclidean Distance 301.578 µm
Max Path Distance 340.095 µm
Max Branch Order 5.0
Average Contraction 0.963667
Total Fragmentation 1095.0
Partition Asymmetry 0.195791
Average Rall's Ratio 0.882778
Average Bifurcation Angle Local 68.6827 °
Average Bifurcation Angle Remote 63.4464 °
Fractal Dimension 1.00569
Complexity Summary
State Equations 1003
Optimal Time-Step 0.00777 ms
Relative Complexity 214.52 HH
Model Size
Sections 43
Compartments 225
State Equations 1003
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00777 ms
Optimal Time-Step Error 0.08 %
Optimal Time-Step Benchmark Run Time 214.52 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 0.56 %
Max. Stable Time-Step Benchmark Run Time 416.62 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 14872 Hz
CVODE Steps Per AP 708
CVODE Benchmark Run Time 240.65 HH
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