Layer 4 Continuous Accommodating Spiny Stellate Cell (3)

Model Type:
Cell
Neurolex IDs: Neocortex Layer 4
Spiny Stellate Cell
Keywords: continuous accommodating for pyramidal cells,Layer 4,excitatory, neocortex, rat, somatosensory cortex, spiny, stellate
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000654
cADpyr230_L4_SS_9e49de205b_0_0.cell.nml
( view NeuroML )
NMLCH000102
Ca_HVA.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000654
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Delayed Regular Spikers (dRS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -73.90 mV
Rheobase Current Interval (0.06294, 0.06546] nA
Threshold Current Interval (0.58594, 0.64453] nA
Bias Current (to -80.00 mV) -0.0290 nA
Testing Temperature 34.0 °C
Stability Interval [-7.1875, 15.0] nA
AP 1-2 Amplitude Drop 1.2061 mV
AP 1 Steady State Amplitude Change 0.5448 mV
AP 1 Amplitude 93.5904 mV
AP 1 Width at Half Height 0.6500 ms
AP 1 Width (Peak To Trough) 2.6200 ms
AP 1 Rate of Change Peak to Trough -40.3266 mV/ms
AP 1 AHP Depth 12.0652 mV
AP2 Amplitude 92.3843 mV
AP2 Width at Half Height 0.6500 ms
AP 2 Width (Peak to Trough) 2.6900 ms
AP 2 Rate of Change Peak to Trough -38.9165 mV/ms
AP 2 AHP Depth 12.3010 mV
AP 1-2 Amplitude Change Percent -1.2887 %
AP 1-2 Half Width Change Percent 0.0000 %
AP 1-2 Rate of Change Peak to Trough Percent Change -3.4967 %
AP 1-2 AHP Depth Percent Change 1.9543 %
Input Resistance 204.9345 MΩ
AP 1 Delay Mean 54.7100 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 133.4400 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 127.1650 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -33.3333 %
Steady State Accommodation Mean -66.6667 %
Accommodation Rate to Steady State N/A %/ms
Accommodation at Steady State Mean -75.9222 %
Accommodation Rate Mean at Steady State 259.7845 ms
ISI CV 3.0438
ISI Median 302.0800 ms
ISI Burst Mean Change 123.0408 %
Spike Rate (Strong Stimulation) 6.5000 Hz
AP 1 Delay Mean (Strong Stimulation) 17.8700 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 48.0400 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 39.1800 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2065.5400 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 118.0253 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 7192.7 µm2
Number of Stems 6.0
Number of Bifurcations 37.0
Number of Branches 79.0
Overall Width 362.696 µm
Overall Height 388.01 µm
Overall Depth 281.06 µm
Average Diameter 0.704087 µm
Total Length 5626.5 µm
Total Surface 11216.5 µm2
Total Volume 3675.34 µm3
Max Euclidean Distance 318.936 µm
Max Path Distance 385.298 µm
Max Branch Order 6.0
Average Contraction 0.97544
Total Fragmentation 1530.0
Partition Asymmetry 0.453808
Average Rall's Ratio 1.72136
Average Bifurcation Angle Local 59.5829 °
Average Bifurcation Angle Remote 66.2147 °
Fractal Dimension 1.00548
Complexity Summary
State Equations 601
Optimal Time-Step 0.00755 ms
Relative Complexity 117.72 HH
Model Size
Sections 80
Compartments 282
State Equations 601
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00755 ms
Optimal Time-Step Error 0.08 %
Optimal Time-Step Benchmark Run Time 117.72 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 0.66 %
Max. Stable Time-Step Benchmark Run Time 222.20 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 12433 Hz
CVODE Steps Per AP 830
CVODE Benchmark Run Time 121.19 HH
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