Layer 4 Continuous Accommodating Spiny Stellate Cell (2)

Model Type:
Cell
Neurolex IDs: Neocortex Layer 4
Spiny Stellate Cell
Keywords: continuous accommodating for pyramidal cells,Layer 4,excitatory, neocortex, rat, somatosensory cortex, spiny, stellate
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000653
cADpyr230_L4_SS_1afeb14f17_0_0.cell.nml
( view NeuroML )
NMLCH000102
Ca_HVA.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000653
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Delayed Regular Spikers (dRS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -73.91 mV
Rheobase Current Interval (0.06042, 0.06294] nA
Threshold Current Interval (0.58594, 0.64453] nA
Bias Current (to -80.00 mV) -0.0290 nA
Testing Temperature 34.0 °C
Stability Interval [-7.1875, 15.0] nA
AP 1-2 Amplitude Drop 1.0450 mV
AP 1 Steady State Amplitude Change 0.3867 mV
AP 1 Amplitude 93.2161 mV
AP 1 Width at Half Height 0.6600 ms
AP 1 Width (Peak To Trough) 2.7000 ms
AP 1 Rate of Change Peak to Trough -39.0572 mV/ms
AP 1 AHP Depth 12.2385 mV
AP2 Amplitude 92.1710 mV
AP2 Width at Half Height 0.6400 ms
AP 2 Width (Peak to Trough) 2.7900 ms
AP 2 Rate of Change Peak to Trough -37.4833 mV/ms
AP 2 AHP Depth 12.4074 mV
AP 1-2 Amplitude Change Percent -1.1211 %
AP 1-2 Half Width Change Percent -3.0303 %
AP 1-2 Rate of Change Peak to Trough Percent Change -4.0298 %
AP 1-2 AHP Depth Percent Change 1.3803 %
Input Resistance 206.8581 MΩ
AP 1 Delay Mean 58.5200 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 144.4300 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 139.9200 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -66.6667 %
Steady State Accommodation Mean -66.6667 %
Accommodation Rate to Steady State N/A %/ms
Accommodation at Steady State Mean -74.4201 %
Accommodation Rate Mean at Steady State 264.2808 ms
ISI CV 3.1575
ISI Median 315.1500 ms
ISI Burst Mean Change 125.7362 %
Spike Rate (Strong Stimulation) 6.5000 Hz
AP 1 Delay Mean (Strong Stimulation) 18.7400 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 50.0300 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 41.4000 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2099.3000 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 120.8837 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 7192.7 µm2
Number of Stems 6.0
Number of Bifurcations 37.0
Number of Branches 79.0
Overall Width 401.241 µm
Overall Height 406.06 µm
Overall Depth 314.13 µm
Average Diameter 0.704087 µm
Total Length 5560.88 µm
Total Surface 11145.4 µm2
Total Volume 3675.32 µm3
Max Euclidean Distance 342.408 µm
Max Path Distance 408.735 µm
Max Branch Order 6.0
Average Contraction 0.975489
Total Fragmentation 1530.0
Partition Asymmetry 0.453808
Average Rall's Ratio 1.72136
Average Bifurcation Angle Local 58.1085 °
Average Bifurcation Angle Remote 64.101 °
Fractal Dimension 1.00538
Complexity Summary
State Equations 593
Optimal Time-Step 0.00767 ms
Relative Complexity 116.27 HH
Model Size
Sections 80
Compartments 278
State Equations 593
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00767 ms
Optimal Time-Step Error 0.06 %
Optimal Time-Step Benchmark Run Time 116.27 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 0.44 %
Max. Stable Time-Step Benchmark Run Time 222.99 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 12491 Hz
CVODE Steps Per AP 811
CVODE Benchmark Run Time 120.86 HH
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