Layer 4 Continuous Accommodating Spiny Stellate Cell (1)

Model Type:
Cell
Neurolex IDs: Neocortex Layer 4
Spiny Stellate Cell
Keywords: continuous accommodating for pyramidal cells,Layer 4,excitatory, neocortex, rat, somatosensory cortex, spiny, stellate
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000652
cADpyr230_L4_SS_08eefff078_0_0.cell.nml
( view NeuroML )
NMLCH000102
Ca_HVA.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000652
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Accommodating Wide AP Multi-Spikers (awMS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -73.62 mV
Rheobase Current Interval (0.06042, 0.06294] nA
Threshold Current Interval (0.58594, 0.64453] nA
Bias Current (to -80.00 mV) -0.0284 nA
Testing Temperature 34.0 °C
Stability Interval [-2.5, 15.0] nA
AP 1-2 Amplitude Drop 1.7998 mV
AP 1 Steady State Amplitude Change 0.9382 mV
AP 1 Amplitude 89.9794 mV
AP 1 Width at Half Height 0.6900 ms
AP 1 Width (Peak To Trough) 10.0300 ms
AP 1 Rate of Change Peak to Trough -10.1174 mV/ms
AP 1 AHP Depth 11.4978 mV
AP2 Amplitude 88.1796 mV
AP2 Width at Half Height 0.6800 ms
AP 2 Width (Peak to Trough) 14.1200 ms
AP 2 Rate of Change Peak to Trough -7.1623 mV/ms
AP 2 AHP Depth 12.9522 mV
AP 1-2 Amplitude Change Percent -2.0003 %
AP 1-2 Half Width Change Percent -1.4493 %
AP 1-2 Rate of Change Peak to Trough Percent Change -29.2078 %
AP 1-2 AHP Depth Percent Change 12.6498 %
Input Resistance 216.6240 MΩ
AP 1 Delay Mean 45.6700 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 131.5100 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 156.5600 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -66.6667 %
Steady State Accommodation Mean -33.3333 %
Accommodation Rate to Steady State -0.0495 %/ms
Accommodation at Steady State Mean -74.3817 %
Accommodation Rate Mean at Steady State 236.5420 ms
ISI CV 3.2706
ISI Median 323.4400 ms
ISI Burst Mean Change 164.7717 %
Spike Rate (Strong Stimulation) 6.0000 Hz
AP 1 Delay Mean (Strong Stimulation) 15.6300 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 48.7300 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 46.6800 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2063.5500 ms
Frequency Filter Type Constant
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 6159.03 µm2
Number of Stems 6.0
Number of Bifurcations 14.0
Number of Branches 33.0
Overall Width 394.741 µm
Overall Height 409.69 µm
Overall Depth 242.6 µm
Average Diameter 0.996131 µm
Total Length 3461.28 µm
Total Surface 8876.84 µm2
Total Volume 3578.41 µm3
Max Euclidean Distance 380.697 µm
Max Path Distance 412.722 µm
Max Branch Order 4.0
Average Contraction 0.947284
Total Fragmentation 759.0
Partition Asymmetry 0.369048
Average Rall's Ratio 0.945833
Average Bifurcation Angle Local 52.2508 °
Average Bifurcation Angle Remote 52.2902 °
Fractal Dimension 1.00775
Complexity Summary
State Equations 561
Optimal Time-Step 0.00784 ms
Relative Complexity 111.26 HH
Model Size
Sections 34
Compartments 176
State Equations 561
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00784 ms
Optimal Time-Step Error 0.20 %
Optimal Time-Step Benchmark Run Time 111.26 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 0.62 %
Max. Stable Time-Step Benchmark Run Time 218.08 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 15925 Hz
CVODE Steps Per AP 573
CVODE Benchmark Run Time 124.23 HH
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