Layer 4 Continuous Accommodating Star Pyramidal Cell (5)

Model Type:
Cell
Neurolex IDs: Neocortex Layer 4
Pyramidal Cell
Keywords: continuous accommodating for pyramidal cells,Layer 4,rat, somatosensory cortex, star, pyramidal, biophysical, continuous accommodating star pyramidal cell, Realistic Network, Neuron or other electrically excitable cell, Synapse, Spatio-temporal Activity Patterns, Detailed Neuronal Models
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000651
cADpyr230_L4_SP_c3f779f565_0_0.cell.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCH001436
Ca_HVA.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000651
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Accommodating Wide AP Multi-Spikers (awMS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -73.03 mV
Rheobase Current Interval (0.05951, 0.06180] nA
Threshold Current Interval (0.52734, 0.58594] nA
Bias Current (to -80.00 mV) -0.0342 nA
Testing Temperature 34.0 °C
Stability Interval [-4.375, 15.0] nA
AP 1-2 Amplitude Drop 2.1991 mV
AP 1 Steady State Amplitude Change 1.1870 mV
AP 1 Amplitude 80.6175 mV
AP 1 Width at Half Height 0.8500 ms
AP 1 Width (Peak To Trough) 18.0500 ms
AP 1 Rate of Change Peak to Trough -4.8790 mV/ms
AP 1 AHP Depth 7.4484 mV
AP2 Amplitude 78.4184 mV
AP2 Width at Half Height 0.8500 ms
AP 2 Width (Peak to Trough) 22.4200 ms
AP 2 Rate of Change Peak to Trough -3.9360 mV/ms
AP 2 AHP Depth 9.8260 mV
AP 1-2 Amplitude Change Percent -2.7279 %
AP 1-2 Half Width Change Percent 0.0000 %
AP 1-2 Rate of Change Peak to Trough Percent Change -19.3284 %
AP 1-2 AHP Depth Percent Change 31.9205 %
Input Resistance 205.0633 MΩ
AP 1 Delay Mean 47.9900 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 131.9400 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 149.7250 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -66.6667 %
Steady State Accommodation Mean -66.6667 %
Accommodation Rate to Steady State N/A %/ms
Accommodation at Steady State Mean -73.9767 %
Accommodation Rate Mean at Steady State 237.6680 ms
ISI CV 3.2741
ISI Median 312.3900 ms
ISI Burst Mean Change 156.7004 %
Spike Rate (Strong Stimulation) 6.5000 Hz
AP 1 Delay Mean (Strong Stimulation) 16.1000 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 48.2000 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 45.0950 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2064.7700 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 73.6187 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 1843.05 µm2
Number of Stems 6.0
Number of Bifurcations 32.0
Number of Branches 69.0
Overall Width 262.174 µm
Overall Height 685.572 µm
Overall Depth 258.62 µm
Average Diameter 0.760371 µm
Total Length 4558.48 µm
Total Surface 10289.7 µm2
Total Volume 2458.12 µm3
Max Euclidean Distance 732.726 µm
Max Path Distance 752.271 µm
Max Branch Order 6.0
Average Contraction 0.978305
Total Fragmentation 1200.0
Partition Asymmetry 0.39747
Average Rall's Ratio 1.35107
Average Bifurcation Angle Local 62.4298 °
Average Bifurcation Angle Remote 60.5882 °
Fractal Dimension 1.00316
Complexity Summary
Relative Complexity 205.91 HH
State Equations 829
Optimal Time-Step 0.00755 ms
Model Size
Sections 70
Compartments 234
State Equations 829
Variable Time-Step Complexity
CVODE Steady State Step Frequency 16852 Hz
CVODE Steps Per AP 583
CVODE Benchmark Run Time 205.91 HH
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