Layer 4 Continuous Accommodating Star Pyramidal Cell (4)

Model Type:
Cell
Neurolex IDs: Neocortex Layer 4
Pyramidal Cell
Keywords: continuous accommodating for pyramidal cells,Layer 4,rat, somatosensory cortex, star, pyramidal
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000650
cADpyr230_L4_SP_6fe41ae9cd_0_0.cell.nml
( view NeuroML )
NMLCH000102
Ca_HVA.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000650
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Accommodating Wide AP Multi-Spikers (awMS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -73.42 mV
Rheobase Current Interval (0.09064, 0.09338] nA
Threshold Current Interval (0.64453, 0.70312] nA
Bias Current (to -80.00 mV) -0.0397 nA
Testing Temperature 34.0 °C
Stability Interval [-4.375, 15.0] nA
AP 1-2 Amplitude Drop 1.8164 mV
AP 1 Steady State Amplitude Change 0.9980 mV
AP 1 Amplitude 95.6862 mV
AP 1 Width at Half Height 0.6300 ms
AP 1 Width (Peak To Trough) 1.9100 ms
AP 1 Rate of Change Peak to Trough -54.6952 mV/ms
AP 1 AHP Depth 8.7816 mV
AP2 Amplitude 93.8698 mV
AP2 Width at Half Height 0.6200 ms
AP 2 Width (Peak to Trough) 2.0500 ms
AP 2 Rate of Change Peak to Trough -50.5220 mV/ms
AP 2 AHP Depth 9.7003 mV
AP 1-2 Amplitude Change Percent -1.8983 %
AP 1-2 Half Width Change Percent -1.5873 %
AP 1-2 Rate of Change Peak to Trough Percent Change -7.6299 %
AP 1-2 AHP Depth Percent Change 10.4617 %
Input Resistance 160.2792 MΩ
AP 1 Delay Mean 35.1100 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 91.7300 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 102.1650 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -66.6667 %
Steady State Accommodation Mean -66.6667 %
Accommodation Rate to Steady State N/A %/ms
Accommodation at Steady State Mean -80.8644 %
Accommodation Rate Mean at Steady State 220.8343 ms
ISI CV 3.0042
ISI Median 269.0650 ms
ISI Burst Mean Change 160.8795 %
Spike Rate (Strong Stimulation) 7.5000 Hz
AP 1 Delay Mean (Strong Stimulation) 11.4600 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 37.2300 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 30.8900 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2054.5500 ms
Frequency Filter Type Band-Pass
Frequency Filter Pass Above 30.5046 Hz
Frequency Filter Pass Below 131.6636 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 9673.1 µm2
Number of Stems 5.0
Number of Bifurcations 35.0
Number of Branches 74.0
Overall Width 272.846 µm
Overall Height 443.266 µm
Overall Depth 242.3 µm
Average Diameter 0.876875 µm
Total Length 5312.05 µm
Total Surface 12029.4 µm2
Total Volume 4782.39 µm3
Max Euclidean Distance 473.924 µm
Max Path Distance 498.131 µm
Max Branch Order 9.0
Average Contraction 0.974274
Total Fragmentation 1145.0
Partition Asymmetry 0.496972
Average Rall's Ratio 1.11231
Average Bifurcation Angle Local 54.686 °
Average Bifurcation Angle Remote 61.6535 °
Fractal Dimension 1.00544
Complexity Summary
State Equations 1075
Optimal Time-Step 0.00757 ms
Relative Complexity 241.78 HH
Model Size
Sections 75
Compartments 273
State Equations 1075
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00757 ms
Optimal Time-Step Error 0.06 %
Optimal Time-Step Benchmark Run Time 241.78 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 0.46 %
Max. Stable Time-Step Benchmark Run Time 457.56 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 16391 Hz
CVODE Steps Per AP 698
CVODE Benchmark Run Time 281.32 HH
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