Layer 4 Continuous Accommodating Star Pyramidal Cell (1)

Model Type:
Cell
Neurolex IDs: Neocortex Layer 4
Pyramidal Cell
Keywords: continuous accommodating for pyramidal cells,Layer 4,rat, somatosensory cortex, star, pyramidal
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000647
cADpyr230_L4_SP_0dc3a9acaf_0_0.cell.nml
( view NeuroML )
NMLCH000102
Ca_HVA.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000647
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Accommodating Wide AP Multi-Spikers (awMS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -72.96 mV
Rheobase Current Interval (0.06042, 0.06294] nA
Threshold Current Interval (0.58594, 0.64453] nA
Bias Current (to -80.00 mV) -0.0340 nA
Testing Temperature 34.0 °C
Stability Interval [-2.8125, 15.0] nA
AP 1-2 Amplitude Drop 1.2614 mV
AP 1 Steady State Amplitude Change 0.5779 mV
AP 1 Amplitude 84.1696 mV
AP 1 Width at Half Height 0.7800 ms
AP 1 Width (Peak To Trough) 14.0200 ms
AP 1 Rate of Change Peak to Trough -6.8404 mV/ms
AP 1 AHP Depth 11.7323 mV
AP2 Amplitude 82.9082 mV
AP2 Width at Half Height 0.7900 ms
AP 2 Width (Peak to Trough) 16.8700 ms
AP 2 Rate of Change Peak to Trough -5.6792 mV/ms
AP 2 AHP Depth 12.8997 mV
AP 1-2 Amplitude Change Percent -1.4986 %
AP 1-2 Half Width Change Percent 1.2821 %
AP 1-2 Rate of Change Peak to Trough Percent Change -16.9753 %
AP 1-2 AHP Depth Percent Change 9.9510 %
Input Resistance 204.1328 MΩ
AP 1 Delay Mean 49.0500 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 140.1300 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 146.0050 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -66.6667 %
Steady State Accommodation Mean -66.6667 %
Accommodation Rate to Steady State N/A %/ms
Accommodation at Steady State Mean -71.4783 %
Accommodation Rate Mean at Steady State 259.6974 ms
ISI CV 3.3488
ISI Median 305.7900 ms
ISI Burst Mean Change 120.6083 %
Spike Rate (Strong Stimulation) 7.0000 Hz
AP 1 Delay Mean (Strong Stimulation) 16.2500 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 51.5200 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 47.2950 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2086.1400 ms
Frequency Filter Type Constant
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 1843.05 µm2
Number of Stems 6.0
Number of Bifurcations 32.0
Number of Branches 69.0
Overall Width 225.547 µm
Overall Height 711.708 µm
Overall Depth 210.64 µm
Average Diameter 0.76186 µm
Total Length 4469.03 µm
Total Surface 10373.7 µm2
Total Volume 2532.73 µm3
Max Euclidean Distance 803.034 µm
Max Path Distance 825.405 µm
Max Branch Order 6.0
Average Contraction 0.978192
Total Fragmentation 1196.0
Partition Asymmetry 0.39747
Average Rall's Ratio 1.35107
Average Bifurcation Angle Local 62.334 °
Average Bifurcation Angle Remote 60.1279 °
Fractal Dimension 1.00445
Complexity Summary
State Equations 825
Optimal Time-Step 0.00786 ms
Relative Complexity 167.82 HH
Model Size
Sections 70
Compartments 228
State Equations 825
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00786 ms
Optimal Time-Step Error 0.17 %
Optimal Time-Step Benchmark Run Time 167.82 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 0.48 %
Max. Stable Time-Step Benchmark Run Time 329.82 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 16943 Hz
CVODE Steps Per AP 446
CVODE Benchmark Run Time 185.75 HH
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