Layer 4 Continuous Accommodating Pyramidal Cell (5)

Model Type:
Cell
Neurolex IDs: Neocortex Layer 4
Pyramidal Cell
Keywords: continuous accommodating for pyramidal cells,Layer 4,principal neuron, neocortex, rat, somatosensory cortex, pyramidal
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000646
cADpyr230_L4_PC_f15e35e578_0_0.cell.nml
( view NeuroML )
NMLCH000102
Ca_HVA.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000646
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Accommodating Wide AP Multi-Spikers (awMS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -72.37 mV
Rheobase Current Interval (0.13618, 0.14008] nA
Threshold Current Interval (0.93750, 0.99609] nA
Bias Current (to -80.00 mV) -0.0712 nA
Testing Temperature 34.0 °C
Stability Interval [-6.25, 15.0] nA
AP 1-2 Amplitude Drop 2.2601 mV
AP 1 Steady State Amplitude Change 2.7992 mV
AP 1 Amplitude 84.2824 mV
AP 1 Width at Half Height 0.7100 ms
AP 1 Width (Peak To Trough) 6.1900 ms
AP 1 Rate of Change Peak to Trough -14.5292 mV/ms
AP 1 AHP Depth 5.6532 mV
AP2 Amplitude 82.0223 mV
AP2 Width at Half Height 0.7100 ms
AP 2 Width (Peak to Trough) 10.3400 ms
AP 2 Rate of Change Peak to Trough -8.6175 mV/ms
AP 2 AHP Depth 7.0827 mV
AP 1-2 Amplitude Change Percent -2.6816 %
AP 1-2 Half Width Change Percent -0.0000 %
AP 1-2 Rate of Change Peak to Trough Percent Change -40.6883 %
AP 1-2 AHP Depth Percent Change 25.2857 %
Input Resistance 105.0688 MΩ
AP 1 Delay Mean 32.8300 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 85.5500 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 97.2400 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -66.6667 %
Steady State Accommodation Mean -66.6667 %
Accommodation Rate to Steady State N/A %/ms
Accommodation at Steady State Mean -81.4053 %
Accommodation Rate Mean at Steady State 215.8635 ms
ISI CV 2.9738
ISI Median 259.0900 ms
ISI Burst Mean Change 168.8923 %
Spike Rate (Strong Stimulation) 8.0000 Hz
AP 1 Delay Mean (Strong Stimulation) 10.1400 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 33.4200 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 28.1600 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2029.6700 ms
Frequency Filter Type Band-Pass
Frequency Filter Pass Above 49.3263 Hz
Frequency Filter Pass Below 117.9722 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 9522.68 µm2
Number of Stems 7.0
Number of Bifurcations 98.0
Number of Branches 202.0
Overall Width 341.298 µm
Overall Height 825.378 µm
Overall Depth 330.16 µm
Average Diameter 0.732868 µm
Total Length 10480.0 µm
Total Surface 20086.0 µm2
Total Volume 6315.61 µm3
Max Euclidean Distance 674.088 µm
Max Path Distance 772.857 µm
Max Branch Order 16.0
Average Contraction 0.984811
Total Fragmentation 1791.0
Partition Asymmetry 0.497092
Average Rall's Ratio 0.993833
Average Bifurcation Angle Local 48.5409 °
Average Bifurcation Angle Remote 50.7229 °
Fractal Dimension 1.00428
Complexity Summary
State Equations 1831
Optimal Time-Step 0.00773 ms
Relative Complexity 416.37 HH
Model Size
Sections 203
Compartments 535
State Equations 1831
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00773 ms
Optimal Time-Step Error 0.19 %
Optimal Time-Step Benchmark Run Time 416.37 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 0.76 %
Max. Stable Time-Step Benchmark Run Time 804.40 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 16573 Hz
CVODE Steps Per AP 683
CVODE Benchmark Run Time 495.16 HH
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