Layer 4 Continuous Accommodating Pyramidal Cell (4)

Model Type:
Cell
Neurolex IDs: Neocortex Layer 4
Pyramidal Cell
Keywords: continuous accommodating for pyramidal cells,Layer 4,principal neuron, neocortex, rat, somatosensory cortex, pyramidal
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000645
cADpyr230_L4_PC_d3b8beb606_0_0.cell.nml
( view NeuroML )
NMLCH000102
Ca_HVA.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000645
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Accommodating Wide AP Multi-Spikers (awMS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -72.91 mV
Rheobase Current Interval (0.07301, 0.07553] nA
Threshold Current Interval (0.58594, 0.64453] nA
Bias Current (to -80.00 mV) -0.0393 nA
Testing Temperature 34.0 °C
Stability Interval [-2.5, 15.0] nA
AP 1-2 Amplitude Drop 1.8467 mV
AP 1 Steady State Amplitude Change 1.3365 mV
AP 1 Amplitude 87.5594 mV
AP 1 Width at Half Height 0.7100 ms
AP 1 Width (Peak To Trough) 8.9600 ms
AP 1 Rate of Change Peak to Trough -10.4964 mV/ms
AP 1 AHP Depth 6.4884 mV
AP2 Amplitude 85.7127 mV
AP2 Width at Half Height 0.7200 ms
AP 2 Width (Peak to Trough) 15.5700 ms
AP 2 Rate of Change Peak to Trough -6.0080 mV/ms
AP 2 AHP Depth 7.8316 mV
AP 1-2 Amplitude Change Percent -2.1091 %
AP 1-2 Half Width Change Percent 1.4085 %
AP 1-2 Rate of Change Peak to Trough Percent Change -42.7615 %
AP 1-2 AHP Depth Percent Change 20.7011 %
Input Resistance 177.9703 MΩ
AP 1 Delay Mean 39.2000 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 103.9100 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 117.1150 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -33.3333 %
Steady State Accommodation Mean -33.3333 %
Accommodation Rate to Steady State -0.0411 %/ms
Accommodation at Steady State Mean -78.2246 %
Accommodation Rate Mean at Steady State 229.7649 ms
ISI CV 3.1806
ISI Median 280.5000 ms
ISI Burst Mean Change 161.9688 %
Spike Rate (Strong Stimulation) 7.0000 Hz
AP 1 Delay Mean (Strong Stimulation) 12.5000 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 39.7700 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 34.5800 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2048.8100 ms
Frequency Filter Type Band-Pass
Frequency Filter Pass Above 40.0064 Hz
Frequency Filter Pass Below 110.4394 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 4721.77 µm2
Number of Stems 9.0
Number of Bifurcations 25.0
Number of Branches 58.0
Overall Width 356.604 µm
Overall Height 625.503 µm
Overall Depth 244.92 µm
Average Diameter 0.821441 µm
Total Length 5288.55 µm
Total Surface 11667.7 µm2
Total Volume 3451.8 µm3
Max Euclidean Distance 545.483 µm
Max Path Distance 608.928 µm
Max Branch Order 6.0
Average Contraction 0.957827
Total Fragmentation 1207.0
Partition Asymmetry 0.573333
Average Rall's Ratio 0.906111
Average Bifurcation Angle Local 70.4234 °
Average Bifurcation Angle Remote 67.5516 °
Fractal Dimension 1.00828
Complexity Summary
State Equations 939
Optimal Time-Step 0.00801 ms
Relative Complexity 189.78 HH
Model Size
Sections 59
Compartments 269
State Equations 939
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00801 ms
Optimal Time-Step Error 0.20 %
Optimal Time-Step Benchmark Run Time 189.78 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 0.72 %
Max. Stable Time-Step Benchmark Run Time 379.85 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 16945 Hz
CVODE Steps Per AP 521
CVODE Benchmark Run Time 221.40 HH
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