Layer 4 Continuous Accommodating Pyramidal Cell (2)

Model Type:
Cell
Neurolex IDs: Neocortex Layer 4
Pyramidal Cell
Keywords: continuous accommodating for pyramidal cells,Layer 4,principal neuron, neocortex, rat, somatosensory cortex, pyramidal
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000643
cADpyr230_L4_PC_2d5807a37b_0_0.cell.nml
( view NeuroML )
NMLCH000102
Ca_HVA.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000643
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Accommodating Wide AP Multi-Spikers (awMS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -72.76 mV
Rheobase Current Interval (0.09064, 0.09338] nA
Threshold Current Interval (0.64453, 0.70312] nA
Bias Current (to -80.00 mV) -0.0497 nA
Testing Temperature 34.0 °C
Stability Interval [-4.6875, 15.0] nA
AP 1-2 Amplitude Drop 2.3887 mV
AP 1 Steady State Amplitude Change 1.4803 mV
AP 1 Amplitude 85.4139 mV
AP 1 Width at Half Height 0.7300 ms
AP 1 Width (Peak To Trough) 13.2900 ms
AP 1 Rate of Change Peak to Trough -6.7511 mV/ms
AP 1 AHP Depth 4.3076 mV
AP2 Amplitude 83.0252 mV
AP2 Width at Half Height 0.7200 ms
AP 2 Width (Peak to Trough) 18.5400 ms
AP 2 Rate of Change Peak to Trough -4.8168 mV/ms
AP 2 AHP Depth 6.2782 mV
AP 1-2 Amplitude Change Percent -2.7966 %
AP 1-2 Half Width Change Percent -1.3699 %
AP 1-2 Rate of Change Peak to Trough Percent Change -28.6512 %
AP 1-2 AHP Depth Percent Change 45.7478 %
Input Resistance 143.4668 MΩ
AP 1 Delay Mean 40.1300 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 96.6800 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 95.0600 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -66.6667 %
Steady State Accommodation Mean -33.3333 %
Accommodation Rate to Steady State -0.0475 %/ms
Accommodation at Steady State Mean -79.6334 %
Accommodation Rate Mean at Steady State 226.2380 ms
ISI CV 3.1852
ISI Median 254.0800 ms
ISI Burst Mean Change 136.1981 %
Spike Rate (Strong Stimulation) 8.5000 Hz
AP 1 Delay Mean (Strong Stimulation) 12.5100 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 37.6300 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 29.9500 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2048.7700 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 111.4315 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 3461.96 µm2
Number of Stems 7.0
Number of Bifurcations 43.0
Number of Branches 92.0
Overall Width 407.135 µm
Overall Height 664.105 µm
Overall Depth 322.94 µm
Average Diameter 0.775296 µm
Total Length 6784.04 µm
Total Surface 14724.2 µm2
Total Volume 3738.43 µm3
Max Euclidean Distance 504.128 µm
Max Path Distance 557.871 µm
Max Branch Order 10.0
Average Contraction 0.972559
Total Fragmentation 1450.0
Partition Asymmetry 0.463895
Average Rall's Ratio 1.008
Average Bifurcation Angle Local 53.4862 °
Average Bifurcation Angle Remote 53.4571 °
Fractal Dimension 1.00526
Complexity Summary
State Equations 1287
Optimal Time-Step 0.00766 ms
Relative Complexity 272.11 HH
Model Size
Sections 93
Compartments 347
State Equations 1287
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00766 ms
Optimal Time-Step Error 0.21 %
Optimal Time-Step Benchmark Run Time 272.11 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 0.79 %
Max. Stable Time-Step Benchmark Run Time 520.71 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 17059 Hz
CVODE Steps Per AP 390
CVODE Benchmark Run Time 287.11 HH
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