Layer 2/3 Continuous Accommodating Pyramidal Cell (5)

Model Type:
Cell
Neurolex IDs: Neocortex Layer 2
Neocortex Layer 3
Pyramidal Cell
Keywords: continuous accommodating for pyramidal cells,Layer 2, Layer 3, Layer 2/3,principal neuron, neocortex, rat, somatosensory cortex, pyramidal
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000641
cADpyr229_L23_PC_c2e79db05a_0_0.cell.nml
( view NeuroML )
NMLCH000102
Ca_HVA.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000641
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Accommodating Wide AP Multi-Spikers (awMS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -72.93 mV
Rheobase Current Interval (0.10620, 0.10986] nA
Threshold Current Interval (0.87891, 0.93750] nA
Bias Current (to -80.00 mV) -0.0548 nA
Testing Temperature 34.0 °C
Stability Interval [-6.25, 15.0] nA
AP 1-2 Amplitude Drop -1.3368 mV
AP 1 Steady State Amplitude Change -1.4397 mV
AP 1 Amplitude 74.4859 mV
AP 1 Width at Half Height 1.0500 ms
AP 1 Width (Peak To Trough) 89.0600 ms
AP 1 Rate of Change Peak to Trough -0.9829 mV/ms
AP 1 AHP Depth 13.0486 mV
AP2 Amplitude 75.8227 mV
AP2 Width at Half Height 1.0600 ms
AP 2 Width (Peak to Trough) 85.8500 ms
AP 2 Rate of Change Peak to Trough -1.0298 mV/ms
AP 2 AHP Depth 12.5816 mV
AP 1-2 Amplitude Change Percent 1.7947 %
AP 1-2 Half Width Change Percent 0.9524 %
AP 1-2 Rate of Change Peak to Trough Percent Change 4.7699 %
AP 1-2 AHP Depth Percent Change -3.5792 %
Input Resistance 126.1777 MΩ
AP 1 Delay Mean 194.4700 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 635.7900 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 441.9850 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean 0.0000 %
Steady State Accommodation Mean 0.0000 %
Accommodation Rate to Steady State N/A %/ms
Accommodation at Steady State Mean -0.2313 %
Accommodation Rate Mean at Steady State 10.0000 ms
ISI CV 888.0576
ISI Median 442.1900 ms
ISI Burst Mean Change 0.3014 %
Spike Rate (Strong Stimulation) 4.0000 Hz
AP 1 Delay Mean (Strong Stimulation) 12.0800 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 130.2000 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 204.2300 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2090.8900 ms
Frequency Filter Type Constant
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 4053.57 µm2
Number of Stems 8.0
Number of Bifurcations 51.0
Number of Branches 109.0
Overall Width 293.503 µm
Overall Height 629.947 µm
Overall Depth 339.29 µm
Average Diameter 0.834642 µm
Total Length 7153.22 µm
Total Surface 17083.0 µm2
Total Volume 4619.8 µm3
Max Euclidean Distance 528.927 µm
Max Path Distance 605.177 µm
Max Branch Order 6.0
Average Contraction 0.981527
Total Fragmentation 1344.0
Partition Asymmetry 0.430402
Average Rall's Ratio 1.137
Average Bifurcation Angle Local 52.2839 °
Average Bifurcation Angle Remote 55.8695 °
Fractal Dimension 1.00398
Complexity Summary
State Equations 1117
Optimal Time-Step 0.00771 ms
Relative Complexity 247.10 HH
Model Size
Sections 110
Compartments 366
State Equations 1117
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00771 ms
Optimal Time-Step Error 0.14 %
Optimal Time-Step Benchmark Run Time 247.10 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 0.43 %
Max. Stable Time-Step Benchmark Run Time 476.10 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 18616 Hz
CVODE Steps Per AP -283
CVODE Benchmark Run Time 197.66 HH
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