Layer 2/3 Continuous Accommodating Pyramidal Cell (1)

Model Type:
Cell
Neurolex IDs: Neocortex Layer 2
Neocortex Layer 3
Pyramidal Cell
Keywords: continuous accommodating for pyramidal cells,Layer 2, Layer 3, Layer 2/3,principal neuron, neocortex, rat, somatosensory cortex, pyramidal
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000637
cADpyr229_L23_PC_5ecbf9b163_0_0.cell.nml
( view NeuroML )
NMLCH000102
Ca_HVA.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000637
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Accommodating Wide AP Multi-Spikers (awMS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -73.22 mV
Rheobase Current Interval (0.06180, 0.06409] nA
Threshold Current Interval (0.52734, 0.58594] nA
Bias Current (to -80.00 mV) -0.0417 nA
Testing Temperature 34.0 °C
Stability Interval [-4.6875, 15.0] nA
AP 1-2 Amplitude Drop 1.7399 mV
AP 1 Steady State Amplitude Change 1.7994 mV
AP 1 Amplitude 92.6276 mV
AP 1 Width at Half Height 0.9000 ms
AP 1 Width (Peak To Trough) 72.9400 ms
AP 1 Rate of Change Peak to Trough -1.4129 mV/ms
AP 1 AHP Depth 10.4273 mV
AP2 Amplitude 90.8877 mV
AP2 Width at Half Height 0.8900 ms
AP 2 Width (Peak to Trough) 81.5300 ms
AP 2 Rate of Change Peak to Trough -1.2726 mV/ms
AP 2 AHP Depth 12.8687 mV
AP 1-2 Amplitude Change Percent -1.8783 %
AP 1-2 Half Width Change Percent -1.1111 %
AP 1-2 Rate of Change Peak to Trough Percent Change -9.9270 %
AP 1-2 AHP Depth Percent Change 23.4130 %
Input Resistance 163.6090 MΩ
AP 1 Delay Mean 53.8600 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 473.2700 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 462.2600 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean 0.0000 %
Steady State Accommodation Mean 0.0000 %
Accommodation Rate to Steady State N/A %/ms
Accommodation at Steady State Mean -16.6349 %
Accommodation Rate Mean at Steady State 10.0000 ms
ISI CV 13.2973
ISI Median 502.0950 ms
ISI Burst Mean Change 20.4335 %
Spike Rate (Strong Stimulation) 3.5000 Hz
AP 1 Delay Mean (Strong Stimulation) 17.7100 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 185.4500 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 247.1700 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2098.2200 ms
Frequency Filter Type Constant
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 3668.35 µm2
Number of Stems 6.0
Number of Bifurcations 43.0
Number of Branches 91.0
Overall Width 338.234 µm
Overall Height 537.975 µm
Overall Depth 218.2 µm
Average Diameter 0.756812 µm
Total Length 6199.89 µm
Total Surface 12846.7 µm2
Total Volume 3164.71 µm3
Max Euclidean Distance 443.29 µm
Max Path Distance 486.753 µm
Max Branch Order 7.0
Average Contraction 0.981838
Total Fragmentation 1153.0
Partition Asymmetry 0.394131
Average Rall's Ratio 1.0
Average Bifurcation Angle Local 49.9192 °
Average Bifurcation Angle Remote 52.5803 °
Fractal Dimension 1.00398
Complexity Summary
State Equations 1097
Optimal Time-Step 0.00758 ms
Relative Complexity 234.05 HH
Model Size
Sections 92
Compartments 312
State Equations 1097
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00758 ms
Optimal Time-Step Error 0.07 %
Optimal Time-Step Benchmark Run Time 234.05 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 0.46 %
Max. Stable Time-Step Benchmark Run Time 443.14 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 16520 Hz
CVODE Steps Per AP 1103
CVODE Benchmark Run Time 321.22 HH
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