Layer 6 Continuous Accommodating Small Basket Cell (1)

Model Type:
Cell
Neurolex IDs: Neocortex basket cell
Neocortex Layer 6
Keywords: continuous accommodating,Layer 6,Fast-spiking, interneuron, GABAergic, inhibitory, neocortex, rat, somatosensory cortex, small, basket
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000632
cACint209_L6_SBC_02fff5e56a_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000632
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Delayed Regular Spikers (dRS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -71.63 mV
Rheobase Current Interval (0.01648, 0.01785] nA
Threshold Current Interval (0.29297, 0.35156] nA
Bias Current (to -80.00 mV) -0.0093 nA
Testing Temperature 34.0 °C
Stability Interval [-2.1875, 15.0] nA
AP 1-2 Amplitude Drop 0.1299 mV
AP 1 Steady State Amplitude Change 0.4688 mV
AP 1 Amplitude 70.4760 mV
AP 1 Width at Half Height 0.6500 ms
AP 1 Width (Peak To Trough) 3.8700 ms
AP 1 Rate of Change Peak to Trough -24.0343 mV/ms
AP 1 AHP Depth 22.5366 mV
AP2 Amplitude 70.3461 mV
AP2 Width at Half Height 0.6700 ms
AP 2 Width (Peak to Trough) 4.0100 ms
AP 2 Rate of Change Peak to Trough -22.9884 mV/ms
AP 2 AHP Depth 21.8375 mV
AP 1-2 Amplitude Change Percent -0.1843 %
AP 1-2 Half Width Change Percent 3.0769 %
AP 1-2 Rate of Change Peak to Trough Percent Change -4.3515 %
AP 1-2 AHP Depth Percent Change -3.1024 %
Input Resistance 900.7039 MΩ
AP 1 Delay Mean 84.7500 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 179.4000 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 96.6600 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -50.0000 %
Steady State Accommodation Mean -50.0000 %
Accommodation Rate to Steady State -0.0296 %/ms
Accommodation at Steady State Mean -47.5894 %
Accommodation Rate Mean at Steady State 804.2948 ms
ISI CV 5.8192
ISI Median 143.1200 ms
ISI Burst Mean Change 4.2472 %
Spike Rate (Strong Stimulation) 14.5000 Hz
AP 1 Delay Mean (Strong Stimulation) 31.0000 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 67.6500 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 37.3250 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2113.4700 ms
Frequency Filter Type Constant
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 9325.79 µm2
Number of Stems 5.0
Number of Bifurcations 26.0
Number of Branches 56.0
Overall Width 139.844 µm
Overall Height 246.615 µm
Overall Depth 126.62 µm
Average Diameter 1.33715 µm
Total Length 2159.52 µm
Total Surface 8202.72 µm2
Total Volume 4856.18 µm3
Max Euclidean Distance 261.042 µm
Max Path Distance 319.792 µm
Max Branch Order 6.0
Average Contraction 0.966989
Total Fragmentation 1000.0
Partition Asymmetry 0.447436
Average Rall's Ratio 1.33583
Average Bifurcation Angle Local 27.683 °
Average Bifurcation Angle Remote 61.0108 °
Fractal Dimension 1.00451
Complexity Summary
State Equations 1091
Optimal Time-Step 0.00540 ms
Relative Complexity 380.37 HH
Model Size
Sections 57
Compartments 107
State Equations 1091
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00540 ms
Optimal Time-Step Error 0.02 %
Optimal Time-Step Benchmark Run Time 380.37 HH
 
Maximum Stable Time-Step 0.03125 ms
Maximum Stable Time-Step Error 0.21 %
Max. Stable Time-Step Benchmark Run Time 1026.99 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 16973 Hz
CVODE Steps Per AP 579
CVODE Benchmark Run Time 307.57 HH
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