Layer 6 Continuous Accommodating Nest Basket Cell (5)

Model Type:
Cell
Neurolex IDs: Neocortex basket cell
Neocortex Layer 6
Keywords: continuous accommodating,Layer 6,Fast-spiking, interneuron, GABAergic, inhibitory, neocortex, rat, somatosensory cortex, nest, basket
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000626
cACint209_L6_NBC_ad3dd575d2_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000626
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Delayed Regular Spikers (dRS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -70.97 mV
Rheobase Current Interval (0.01945, 0.02060] nA
Threshold Current Interval (0.23438, 0.29297] nA
Bias Current (to -80.00 mV) -0.0127 nA
Testing Temperature 34.0 °C
Stability Interval [-1.875, 15.0] nA
AP 1-2 Amplitude Drop -0.0149 mV
AP 1 Steady State Amplitude Change 0.5326 mV
AP 1 Amplitude 85.6546 mV
AP 1 Width at Half Height 0.5800 ms
AP 1 Width (Peak To Trough) 3.0500 ms
AP 1 Rate of Change Peak to Trough -33.7833 mV/ms
AP 1 AHP Depth 17.3845 mV
AP2 Amplitude 85.6695 mV
AP2 Width at Half Height 0.5800 ms
AP 2 Width (Peak to Trough) 3.1200 ms
AP 2 Rate of Change Peak to Trough -33.0573 mV/ms
AP 2 AHP Depth 17.4693 mV
AP 1-2 Amplitude Change Percent 0.0173 %
AP 1-2 Half Width Change Percent 0.0000 %
AP 1-2 Rate of Change Peak to Trough Percent Change -2.1491 %
AP 1-2 AHP Depth Percent Change 0.4876 %
Input Resistance 744.1673 MΩ
AP 1 Delay Mean 73.3900 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 145.0800 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 73.3150 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -20.0000 %
Steady State Accommodation Mean -40.0000 %
Accommodation Rate to Steady State -0.0334 %/ms
Accommodation at Steady State Mean -57.2725 %
Accommodation Rate Mean at Steady State 775.8983 ms
ISI CV 4.4969
ISI Median 122.3750 ms
ISI Burst Mean Change 4.5334 %
Spike Rate (Strong Stimulation) 16.5000 Hz
AP 1 Delay Mean (Strong Stimulation) 24.0500 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 50.3600 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 26.9750 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2102.0900 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 71.3727 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 10206.9 µm2
Number of Stems 5.0
Number of Bifurcations 16.0
Number of Branches 36.0
Overall Width 315.349 µm
Overall Height 484.183 µm
Overall Depth 400.32 µm
Average Diameter 0.996532 µm
Total Length 3710.42 µm
Total Surface 9704.77 µm2
Total Volume 5172.12 µm3
Max Euclidean Distance 390.58 µm
Max Path Distance 464.981 µm
Max Branch Order 6.0
Average Contraction 0.959575
Total Fragmentation 2083.0
Partition Asymmetry 0.433333
Average Rall's Ratio 1.10958
Average Bifurcation Angle Local 17.3892 °
Average Bifurcation Angle Remote 60.4375 °
Fractal Dimension 1.00788
Complexity Summary
State Equations 1911
Optimal Time-Step 0.00764 ms
Relative Complexity 447.36 HH
Model Size
Sections 37
Compartments 189
State Equations 1911
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00764 ms
Optimal Time-Step Error 0.11 %
Optimal Time-Step Benchmark Run Time 447.36 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 0.89 %
Max. Stable Time-Step Benchmark Run Time 854.06 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 14839 Hz
CVODE Steps Per AP 397
CVODE Benchmark Run Time 422.55 HH
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