Layer 6 Continuous Accommodating Martinotti Cell (1)

Model Type:
Cell
Neurolex IDs: Martinotti Cell
Neocortex Layer 6
Keywords: continuous accommodating,Layer 6,GABAergic, inhibitory, neocortex, rat, somatosensory cortex, Martinotti
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000617
cACint209_L6_MC_0686f3517c_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000617
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Delayed Regular Spikers (dRS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -70.84 mV
Rheobase Current Interval (0.01785, 0.01923] nA
Threshold Current Interval (0.29297, 0.35156] nA
Bias Current (to -80.00 mV) -0.0111 nA
Testing Temperature 34.0 °C
Stability Interval [-2.1875, 15.0] nA
AP 1-2 Amplitude Drop -1.9470 mV
AP 1 Steady State Amplitude Change -2.7336 mV
AP 1 Amplitude 70.0024 mV
AP 1 Width at Half Height 0.7800 ms
AP 1 Width (Peak To Trough) 5.5200 ms
AP 1 Rate of Change Peak to Trough -13.7697 mV/ms
AP 1 AHP Depth 6.0062 mV
AP2 Amplitude 71.9494 mV
AP2 Width at Half Height 0.7600 ms
AP 2 Width (Peak to Trough) 5.2800 ms
AP 2 Rate of Change Peak to Trough -14.8907 mV/ms
AP 2 AHP Depth 6.6736 mV
AP 1-2 Amplitude Change Percent 2.7813 %
AP 1-2 Half Width Change Percent -2.5641 %
AP 1-2 Rate of Change Peak to Trough Percent Change 8.1414 %
AP 1-2 AHP Depth Percent Change 11.1122 %
Input Resistance 832.4683 MΩ
AP 1 Delay Mean 63.8500 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 118.9000 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 58.9400 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -40.0000 %
Steady State Accommodation Mean -40.0000 %
Accommodation Rate to Steady State -0.0340 %/ms
Accommodation at Steady State Mean -64.7863 %
Accommodation Rate Mean at Steady State 641.7027 ms
ISI CV 3.6775
ISI Median 122.6550 ms
ISI Burst Mean Change 14.1326 %
Spike Rate (Strong Stimulation) 20.0000 Hz
AP 1 Delay Mean (Strong Stimulation) 24.5500 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 45.0400 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 21.8850 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2031.5200 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 120.3067 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 6342.27 µm2
Number of Stems 7.0
Number of Bifurcations 26.0
Number of Branches 58.0
Overall Width 303.547 µm
Overall Height 441.647 µm
Overall Depth 199.43 µm
Average Diameter 0.649388 µm
Total Length 5076.85 µm
Total Surface 10071.3 µm2
Total Volume 3275.13 µm3
Max Euclidean Distance 360.108 µm
Max Path Distance 370.694 µm
Max Branch Order 6.0
Average Contraction 0.969206
Total Fragmentation 3497.0
Partition Asymmetry 0.384615
Average Rall's Ratio 1.29857
Average Bifurcation Angle Local 31.4444 °
Average Bifurcation Angle Remote 49.7147 °
Fractal Dimension 1.00538
Complexity Summary
State Equations 2531
Optimal Time-Step 0.00742 ms
Relative Complexity 634.65 HH
Model Size
Sections 59
Compartments 251
State Equations 2531
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00742 ms
Optimal Time-Step Error 0.24 %
Optimal Time-Step Benchmark Run Time 634.65 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 2.12 %
Max. Stable Time-Step Benchmark Run Time 1176.20 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 16275 Hz
CVODE Steps Per AP 259
CVODE Benchmark Run Time 583.80 HH
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