Layer 6 Continuous Accommodating Double Bouquet Cell (1)

Model Type:
Cell
Neurolex IDs: Double Bouquet Cell
Neocortex Layer 6
Keywords: continuous accommodating,Layer 6,GABAergic, inhibitory, neocortex, rat, somatosensory cortex, double bouquet
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000612
cACint209_L6_DBC_0271760b42_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000612
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Delayed Regular Spikers (dRS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -69.39 mV
Rheobase Current Interval (0.01740, 0.01831] nA
Threshold Current Interval (0.17578, 0.23438] nA
Bias Current (to -80.00 mV) -0.0144 nA
Testing Temperature 34.0 °C
Stability Interval [-2.1875, 15.0] nA
AP 1-2 Amplitude Drop -0.0127 mV
AP 1 Steady State Amplitude Change 0.8762 mV
AP 1 Amplitude 83.5260 mV
AP 1 Width at Half Height 0.6200 ms
AP 1 Width (Peak To Trough) 3.3100 ms
AP 1 Rate of Change Peak to Trough -29.1088 mV/ms
AP 1 AHP Depth 12.8242 mV
AP2 Amplitude 83.5387 mV
AP2 Width at Half Height 0.6100 ms
AP 2 Width (Peak to Trough) 3.3100 ms
AP 2 Rate of Change Peak to Trough -29.1168 mV/ms
AP 2 AHP Depth 12.8380 mV
AP 1-2 Amplitude Change Percent 0.0152 %
AP 1-2 Half Width Change Percent -1.6129 %
AP 1-2 Rate of Change Peak to Trough Percent Change 0.0275 %
AP 1-2 AHP Depth Percent Change 0.1074 %
Input Resistance 726.4971 MΩ
AP 1 Delay Mean 70.8500 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 132.0500 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 62.3650 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -20.0000 %
Steady State Accommodation Mean -40.0000 %
Accommodation Rate to Steady State -0.0376 %/ms
Accommodation at Steady State Mean -59.2527 %
Accommodation Rate Mean at Steady State 582.7605 ms
ISI CV 4.2933
ISI Median 115.8850 ms
ISI Burst Mean Change 3.8072 %
Spike Rate (Strong Stimulation) 18.5000 Hz
AP 1 Delay Mean (Strong Stimulation) 23.4300 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 47.3700 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 24.5200 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2097.3900 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 83.0881 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 8381.24 µm2
Number of Stems 5.0
Number of Bifurcations 37.0
Number of Branches 78.0
Overall Width 170.545 µm
Overall Height 970.074 µm
Overall Depth 177.57 µm
Average Diameter 0.900764 µm
Total Length 4233.05 µm
Total Surface 11290.0 µm2
Total Volume 5843.15 µm3
Max Euclidean Distance 794.795 µm
Max Path Distance 830.014 µm
Max Branch Order 16.0
Average Contraction 0.961823
Total Fragmentation 4757.0
Partition Asymmetry 0.636207
Average Rall's Ratio 0.690357
Average Bifurcation Angle Local 47.0446 °
Average Bifurcation Angle Remote 56.2112 °
Fractal Dimension 1.00843
Complexity Summary
State Equations 2271
Optimal Time-Step 0.00749 ms
Relative Complexity 572.23 HH
Model Size
Sections 79
Compartments 225
State Equations 2271
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00749 ms
Optimal Time-Step Error 0.09 %
Optimal Time-Step Benchmark Run Time 572.23 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 1.06 %
Max. Stable Time-Step Benchmark Run Time 1071.11 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 14059 Hz
CVODE Steps Per AP 509
CVODE Benchmark Run Time 539.47 HH
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