Layer 6 Continuous Accommodating Chandelier Cell (2)

Model Type:
Cell
Neurolex IDs: Neocortex Layer 6
Chandelier Cell
Keywords: continuous accommodating,Layer 6,GABAergic, inhibitory, neocortex, rat, somatosensory cortex, chandelier
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000608
cACint209_L6_ChC_6a369a07f4_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000608
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Delayed Regular Spikers (dRS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -71.45 mV
Rheobase Current Interval (0.01511, 0.01648] nA
Threshold Current Interval (0.29297, 0.35156] nA
Bias Current (to -80.00 mV) -0.0123 nA
Testing Temperature 34.0 °C
Stability Interval [-2.1875, 15.0] nA
AP 1-2 Amplitude Drop -0.1244 mV
AP 1 Steady State Amplitude Change 0.1060 mV
AP 1 Amplitude 81.4008 mV
AP 1 Width at Half Height 0.5700 ms
AP 1 Width (Peak To Trough) 3.5300 ms
AP 1 Rate of Change Peak to Trough -30.2238 mV/ms
AP 1 AHP Depth 25.2893 mV
AP2 Amplitude 81.5253 mV
AP2 Width at Half Height 0.5800 ms
AP 2 Width (Peak to Trough) 3.5100 ms
AP 2 Rate of Change Peak to Trough -30.3385 mV/ms
AP 2 AHP Depth 24.9630 mV
AP 1-2 Amplitude Change Percent 0.1529 %
AP 1-2 Half Width Change Percent 1.7544 %
AP 1-2 Rate of Change Peak to Trough Percent Change 0.3796 %
AP 1-2 AHP Depth Percent Change -1.2900 %
Input Resistance 702.5407 MΩ
AP 1 Delay Mean 83.7300 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 184.5900 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 104.4750 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -33.3333 %
Steady State Accommodation Mean -33.3333 %
Accommodation Rate to Steady State -0.0272 %/ms
Accommodation at Steady State Mean -55.7689 %
Accommodation Rate Mean at Steady State 795.7383 ms
ISI CV 4.5868
ISI Median 166.7200 ms
ISI Burst Mean Change 7.1684 %
Spike Rate (Strong Stimulation) 11.5000 Hz
AP 1 Delay Mean (Strong Stimulation) 29.8500 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 69.9100 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 41.0800 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2110.4600 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 47.4039 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 8533.04 µm2
Number of Stems 6.0
Number of Bifurcations 26.0
Number of Branches 57.0
Overall Width 360.654 µm
Overall Height 592.929 µm
Overall Depth 167.59 µm
Average Diameter 0.974029 µm
Total Length 2819.49 µm
Total Surface 9020.96 µm2
Total Volume 4865.66 µm3
Max Euclidean Distance 417.87 µm
Max Path Distance 472.342 µm
Max Branch Order 11.0
Average Contraction 0.931538
Total Fragmentation 2370.0
Partition Asymmetry 0.571072
Average Rall's Ratio 0.891538
Average Bifurcation Angle Local 55.1722 °
Average Bifurcation Angle Remote 74.3935 °
Fractal Dimension 1.01169
Complexity Summary
State Equations 1581
Optimal Time-Step 0.00764 ms
Relative Complexity 382.29 HH
Model Size
Sections 60
Compartments 156
State Equations 1581
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00764 ms
Optimal Time-Step Error 0.03 %
Optimal Time-Step Benchmark Run Time 382.29 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 0.44 %
Max. Stable Time-Step Benchmark Run Time 730.04 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 15462 Hz
CVODE Steps Per AP 392
CVODE Benchmark Run Time 372.25 HH
Website & Images Copyright NeuroML © 2019 For questions: Contact us Links: Search Test |  ModelDB WS