Layer 6 Continuous Accommodating Bitufted Cell (1)

Model Type:
Cell
Neurolex IDs: Neocortex Layer 6
Keywords: continuous accommodating,Layer 6,Rat, somatosensory cortex, bitufted
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000602
cACint209_L6_BTC_045fb87685_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000602
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Delayed Regular Spikers (dRS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -71.59 mV
Rheobase Current Interval (0.02106, 0.02197] nA
Threshold Current Interval (0.17578, 0.23438] nA
Bias Current (to -80.00 mV) -0.0096 nA
Testing Temperature 34.0 °C
Stability Interval [-1.5625, 15.0] nA
AP 1-2 Amplitude Drop 0.1441 mV
AP 1 Steady State Amplitude Change 1.2939 mV
AP 1 Amplitude 85.8657 mV
AP 1 Width at Half Height 0.5900 ms
AP 1 Width (Peak To Trough) 2.6600 ms
AP 1 Rate of Change Peak to Trough -38.6510 mV/ms
AP 1 AHP Depth 16.9459 mV
AP2 Amplitude 85.7216 mV
AP2 Width at Half Height 0.5900 ms
AP 2 Width (Peak to Trough) 2.7300 ms
AP 2 Rate of Change Peak to Trough -37.7081 mV/ms
AP 2 AHP Depth 17.2215 mV
AP 1-2 Amplitude Change Percent -0.1678 %
AP 1-2 Half Width Change Percent 0.0000 %
AP 1-2 Rate of Change Peak to Trough Percent Change -2.4395 %
AP 1-2 AHP Depth Percent Change 1.6260 %
Input Resistance 859.5152 MΩ
AP 1 Delay Mean 50.2800 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 98.7800 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 50.1250 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -50.0000 %
Steady State Accommodation Mean -50.0000 %
Accommodation Rate to Steady State -0.0498 %/ms
Accommodation at Steady State Mean -70.4726 %
Accommodation Rate Mean at Steady State 450.6768 ms
ISI CV 3.3760
ISI Median 121.2150 ms
ISI Burst Mean Change 6.7010 %
Spike Rate (Strong Stimulation) 17.5000 Hz
AP 1 Delay Mean (Strong Stimulation) 17.5300 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 37.4100 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 20.6400 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2057.7100 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 76.6474 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 10030.0 µm2
Number of Stems 4.0
Number of Bifurcations 34.0
Number of Branches 71.0
Overall Width 444.333 µm
Overall Height 447.775 µm
Overall Depth 261.62 µm
Average Diameter 0.681102 µm
Total Length 5786.12 µm
Total Surface 8077.53 µm2
Total Volume 4145.05 µm3
Max Euclidean Distance 358.23 µm
Max Path Distance 425.731 µm
Max Branch Order 7.0
Average Contraction 0.958861
Total Fragmentation 2481.0
Partition Asymmetry 0.346257
Average Rall's Ratio 1.06735
Average Bifurcation Angle Local 6.48053 °
Average Bifurcation Angle Remote 41.0463 °
Fractal Dimension 1.01153
Complexity Summary
State Equations 2921
Optimal Time-Step 0.00768 ms
Relative Complexity 719.91 HH
Model Size
Sections 72
Compartments 290
State Equations 2921
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00768 ms
Optimal Time-Step Error 0.18 %
Optimal Time-Step Benchmark Run Time 719.91 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 1.23 %
Max. Stable Time-Step Benchmark Run Time 1381.48 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 13746 Hz
CVODE Steps Per AP 744
CVODE Benchmark Run Time 770.17 HH
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