Layer 6 Continuous Accommodating Bipolar Cell (3)

Model Type:
Cell
Neurolex IDs: Bipolar Cell
Neocortex Layer 6
Keywords: continuous accommodating,Layer 6,GABAergic, inhibitory, neocortex, rat, somatosensory cortex, bipolar, biophysical, continuous accommodating bipolar cell, Realistic Network, Neuron or other electrically excitable cell, Synapse, Spatio-temporal Activity Patterns, Detailed Neuronal Models
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000599
cACint209_L6_BP_a6fb2fe3a5_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000599
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Delayed Regular Spikers (dRS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -69.65 mV
Rheobase Current Interval (0.00549, 0.00618] nA
Threshold Current Interval (0.11719, 0.17578] nA
Bias Current (to -80.00 mV) -0.0076 nA
Testing Temperature 34.0 °C
Stability Interval [-1.25, 15.0] nA
AP 1-2 Amplitude Drop -0.0924 mV
AP 1 Steady State Amplitude Change 0.3393 mV
AP 1 Amplitude 85.1746 mV
AP 1 Width at Half Height 0.6200 ms
AP 1 Width (Peak To Trough) 2.5300 ms
AP 1 Rate of Change Peak to Trough -38.0613 mV/ms
AP 1 AHP Depth 11.1206 mV
AP2 Amplitude 85.2670 mV
AP2 Width at Half Height 0.6100 ms
AP 2 Width (Peak to Trough) 2.5200 ms
AP 2 Rate of Change Peak to Trough -38.2894 mV/ms
AP 2 AHP Depth 11.2223 mV
AP 1-2 Amplitude Change Percent 0.1085 %
AP 1-2 Half Width Change Percent -1.6129 %
AP 1-2 Rate of Change Peak to Trough Percent Change 0.5992 %
AP 1-2 AHP Depth Percent Change 0.9146 %
Input Resistance 1464.8556 MΩ
AP 1 Delay Mean 134.1300 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 241.6600 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 109.8250 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean 0.0000 %
Steady State Accommodation Mean 0.0000 %
Accommodation Rate to Steady State 0.0000 %/ms
Accommodation at Steady State Mean -41.0830 %
Accommodation Rate Mean at Steady State 871.2938 ms
ISI CV 7.1339
ISI Median 149.0400 ms
ISI Burst Mean Change 4.2686 %
Spike Rate (Strong Stimulation) 15.0000 Hz
AP 1 Delay Mean (Strong Stimulation) 47.0500 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 83.9100 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 37.9900 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2167.8500 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 124.7891 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 1850.73 µm2
Number of Stems 5.0
Number of Bifurcations 30.0
Number of Branches 64.0
Overall Width 289.183 µm
Overall Height 412.994 µm
Overall Depth 266.55 µm
Average Diameter 0.633331 µm
Total Length 3651.61 µm
Total Surface 6339.99 µm2
Total Volume 1324.58 µm3
Max Euclidean Distance 306.868 µm
Max Path Distance 369.753 µm
Max Branch Order 6.0
Average Contraction 0.971777
Total Fragmentation 1022.0
Partition Asymmetry 0.369444
Average Rall's Ratio 1.11375
Average Bifurcation Angle Local 32.9295 °
Average Bifurcation Angle Remote 50.1185 °
Fractal Dimension 1.00543
Complexity Summary
Relative Complexity 402.83 HH
State Equations 1891
Optimal Time-Step 0.00777 ms
Model Size
Sections 65
Compartments 187
State Equations 1891
Variable Time-Step Complexity
CVODE Steady State Step Frequency 15145 Hz
CVODE Steps Per AP 284
CVODE Benchmark Run Time 402.83 HH
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