Layer 5 Continuous Accommodating Small Basket Cell (2)

Model Type:
Cell
Neurolex IDs: Neocortex basket cell
Neocortex Layer 5
Keywords: continuous accommodating,Layer 5,Fast-spiking, interneuron, GABAergic, inhibitory, neocortex, rat, somatosensory cortex, small, basket, biophysical, continuous accommodating small basket cell, Realistic Network, Neuron or other electrically excitable cell, Synapse, Spatio-temporal Activity Patterns, Detailed Neuronal Models
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000593
cACint209_L5_SBC_3ba116236f_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000593
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Delayed Regular Spikers (dRS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -69.70 mV
Rheobase Current Interval (0.02060, 0.02174] nA
Threshold Current Interval (0.23438, 0.29297] nA
Bias Current (to -80.00 mV) -0.0168 nA
Testing Temperature 34.0 °C
Stability Interval [-1.5625, 15.0] nA
AP 1-2 Amplitude Drop -0.0412 mV
AP 1 Steady State Amplitude Change 0.6872 mV
AP 1 Amplitude 78.1689 mV
AP 1 Width at Half Height 0.6600 ms
AP 1 Width (Peak To Trough) 2.8700 ms
AP 1 Rate of Change Peak to Trough -31.2701 mV/ms
AP 1 AHP Depth 11.5764 mV
AP2 Amplitude 78.2101 mV
AP2 Width at Half Height 0.6500 ms
AP 2 Width (Peak to Trough) 2.8900 ms
AP 2 Rate of Change Peak to Trough -31.1035 mV/ms
AP 2 AHP Depth 11.6790 mV
AP 1-2 Amplitude Change Percent 0.0527 %
AP 1-2 Half Width Change Percent -1.5152 %
AP 1-2 Rate of Change Peak to Trough Percent Change -0.5328 %
AP 1-2 AHP Depth Percent Change 0.8866 %
Input Resistance 643.6825 MΩ
AP 1 Delay Mean 69.9600 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 114.6900 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 46.1000 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -33.3333 %
Steady State Accommodation Mean -50.0000 %
Accommodation Rate to Steady State -0.0487 %/ms
Accommodation at Steady State Mean -68.0174 %
Accommodation Rate Mean at Steady State 406.2251 ms
ISI CV 3.6811
ISI Median 108.1350 ms
ISI Burst Mean Change 6.1256 %
Spike Rate (Strong Stimulation) 20.0000 Hz
AP 1 Delay Mean (Strong Stimulation) 24.1300 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 43.3300 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 19.8850 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2104.3700 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 98.8210 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 9079.56 µm2
Number of Stems 4.0
Number of Bifurcations 55.0
Number of Branches 113.0
Overall Width 397.414 µm
Overall Height 707.578 µm
Overall Depth 185.99 µm
Average Diameter 0.71045 µm
Total Length 5810.53 µm
Total Surface 12780.4 µm2
Total Volume 5364.89 µm3
Max Euclidean Distance 459.173 µm
Max Path Distance 654.813 µm
Max Branch Order 10.0
Average Contraction 0.930719
Total Fragmentation 6531.0
Partition Asymmetry 0.519756
Average Rall's Ratio 0.798152
Average Bifurcation Angle Local 52.7972 °
Average Bifurcation Angle Remote 68.9831 °
Fractal Dimension 1.01646
Complexity Summary
Relative Complexity 691.52 HH
State Equations 3121
Optimal Time-Step 0.00545 ms
Model Size
Sections 114
Compartments 310
State Equations 3121
Variable Time-Step Complexity
CVODE Steady State Step Frequency 14071 Hz
CVODE Steps Per AP 408
CVODE Benchmark Run Time 691.52 HH
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