Layer 5 Continuous Accommodating Nest Basket Cell (3)

Model Type:
Cell
Neurolex IDs: Neocortex basket cell
Neocortex Layer 5
Keywords: continuous accommodating,Layer 5,Fast-spiking, interneuron, GABAergic, inhibitory, neocortex, rat, somatosensory cortex, nest, basket
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000584
cACint209_L5_NBC_63fe8b2e25_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000584
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Delayed Regular Spikers (dRS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -69.73 mV
Rheobase Current Interval (0.01099, 0.01190] nA
Threshold Current Interval (0.17578, 0.23438] nA
Bias Current (to -80.00 mV) -0.0164 nA
Testing Temperature 34.0 °C
Stability Interval [-1.5625, 15.0] nA
AP 1-2 Amplitude Drop -0.0338 mV
AP 1 Steady State Amplitude Change 0.1280 mV
AP 1 Amplitude 85.3875 mV
AP 1 Width at Half Height 0.5400 ms
AP 1 Width (Peak To Trough) 2.8100 ms
AP 1 Rate of Change Peak to Trough -38.8161 mV/ms
AP 1 AHP Depth 23.6857 mV
AP2 Amplitude 85.4214 mV
AP2 Width at Half Height 0.5400 ms
AP 2 Width (Peak to Trough) 2.8100 ms
AP 2 Rate of Change Peak to Trough -38.8874 mV/ms
AP 2 AHP Depth 23.8521 mV
AP 1-2 Amplitude Change Percent 0.0396 %
AP 1-2 Half Width Change Percent -0.0000 %
AP 1-2 Rate of Change Peak to Trough Percent Change 0.1836 %
AP 1-2 AHP Depth Percent Change 0.7026 %
Input Resistance 653.8967 MΩ
AP 1 Delay Mean 106.3500 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 222.1600 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 119.9650 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -33.3333 %
Steady State Accommodation Mean -33.3333 %
Accommodation Rate to Steady State -0.0245 %/ms
Accommodation at Steady State Mean -48.6213 %
Accommodation Rate Mean at Steady State 795.3338 ms
ISI CV 5.5413
ISI Median 178.4700 ms
ISI Burst Mean Change 7.1755 %
Spike Rate (Strong Stimulation) 11.5000 Hz
AP 1 Delay Mean (Strong Stimulation) 36.0800 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 80.8700 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 45.5850 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2131.8700 ms
Frequency Filter Type Constant
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 5354.07 µm2
Number of Stems 5.0
Number of Bifurcations 34.0
Number of Branches 72.0
Overall Width 431.103 µm
Overall Height 601.091 µm
Overall Depth 179.41 µm
Average Diameter 0.698947 µm
Total Length 5586.0 µm
Total Surface 11014.0 µm2
Total Volume 3511.69 µm3
Max Euclidean Distance 684.957 µm
Max Path Distance 872.822 µm
Max Branch Order 11.0
Average Contraction 0.957767
Total Fragmentation 2033.0
Partition Asymmetry 0.53421
Average Rall's Ratio 1.3125
Average Bifurcation Angle Local 50.3752 °
Average Bifurcation Angle Remote 68.0443 °
Fractal Dimension 1.00734
Complexity Summary
State Equations 2791
Optimal Time-Step 0.00798 ms
Relative Complexity 639.65 HH
Model Size
Sections 73
Compartments 277
State Equations 2791
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00798 ms
Optimal Time-Step Error 0.04 %
Optimal Time-Step Benchmark Run Time 639.65 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 0.62 %
Max. Stable Time-Step Benchmark Run Time 1275.61 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 15332 Hz
CVODE Steps Per AP 429
CVODE Benchmark Run Time 658.44 HH
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