Layer 5 Continuous Accommodating Martinotti Cell (1)

Model Type:
Cell
Neurolex IDs: Martinotti Cell
Neocortex Layer 5
Keywords: continuous accommodating,Layer 5,GABAergic, inhibitory, neocortex, rat, somatosensory cortex, Martinotti
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000577
cACint209_L5_MC_42542e071a_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000577
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Delayed Regular Spikers (dRS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -69.48 mV
Rheobase Current Interval (0.01259, 0.01373] nA
Threshold Current Interval (0.23438, 0.29297] nA
Bias Current (to -80.00 mV) -0.0185 nA
Testing Temperature 34.0 °C
Stability Interval [-2.1875, 15.0] nA
AP 1-2 Amplitude Drop -0.2660 mV
AP 1 Steady State Amplitude Change 0.2711 mV
AP 1 Amplitude 81.2503 mV
AP 1 Width at Half Height 0.6300 ms
AP 1 Width (Peak To Trough) 3.2500 ms
AP 1 Rate of Change Peak to Trough -29.1765 mV/ms
AP 1 AHP Depth 13.5733 mV
AP2 Amplitude 81.5163 mV
AP2 Width at Half Height 0.6400 ms
AP 2 Width (Peak to Trough) 3.2500 ms
AP 2 Rate of Change Peak to Trough -29.1907 mV/ms
AP 2 AHP Depth 13.3535 mV
AP 1-2 Amplitude Change Percent 0.3274 %
AP 1-2 Half Width Change Percent 1.5873 %
AP 1-2 Rate of Change Peak to Trough Percent Change 0.0487 %
AP 1-2 AHP Depth Percent Change -1.6192 %
Input Resistance 665.7335 MΩ
AP 1 Delay Mean 122.4500 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 229.1200 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 108.9950 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean 0.0000 %
Steady State Accommodation Mean 0.0000 %
Accommodation Rate to Steady State 0.0000 %/ms
Accommodation at Steady State Mean -42.3761 %
Accommodation Rate Mean at Steady State 930.4293 ms
ISI CV 6.9442
ISI Median 148.0800 ms
ISI Burst Mean Change 4.3592 %
Spike Rate (Strong Stimulation) 15.0000 Hz
AP 1 Delay Mean (Strong Stimulation) 42.0000 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 79.2100 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 38.0600 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2164.8000 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 81.9169 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 6011.66 µm2
Number of Stems 3.0
Number of Bifurcations 71.0
Number of Branches 144.0
Overall Width 335.154 µm
Overall Height 638.17 µm
Overall Depth 143.39 µm
Average Diameter 0.683045 µm
Total Length 6251.91 µm
Total Surface 11798.5 µm2
Total Volume 3764.55 µm3
Max Euclidean Distance 526.641 µm
Max Path Distance 645.646 µm
Max Branch Order 13.0
Average Contraction 0.973664
Total Fragmentation 2300.0
Partition Asymmetry 0.576985
Average Rall's Ratio 0.920116
Average Bifurcation Angle Local 54.6935 °
Average Bifurcation Angle Remote 56.9213 °
Fractal Dimension 1.00433
Complexity Summary
State Equations 3271
Optimal Time-Step 0.00782 ms
Relative Complexity 828.07 HH
Model Size
Sections 141
Compartments 325
State Equations 3271
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00782 ms
Optimal Time-Step Error 0.04 %
Optimal Time-Step Benchmark Run Time 828.07 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 0.63 %
Max. Stable Time-Step Benchmark Run Time 1617.87 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 15081 Hz
CVODE Steps Per AP 281
CVODE Benchmark Run Time 761.71 HH
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