Layer 5 Continuous Accommodating Large Basket Cell (1)

Model Type:
Cell
Neurolex IDs: Neocortex basket cell
Neocortex Layer 5
Keywords: continuous accommodating,Layer 5,Fast-spiking, interneuron, GABAergic, inhibitory, neocortex, rat, somatosensory cortex, large, basket
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000572
cACint209_L5_LBC_09c47b4905_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000572
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Delayed Regular Spikers (dRS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -70.61 mV
Rheobase Current Interval (0.01923, 0.02083] nA
Threshold Current Interval (0.35156, 0.41016] nA
Bias Current (to -80.00 mV) -0.0174 nA
Testing Temperature 34.0 °C
Stability Interval [-3.125, 15.0] nA
AP 1-2 Amplitude Drop -0.1882 mV
AP 1 Steady State Amplitude Change 0.4010 mV
AP 1 Amplitude 80.1573 mV
AP 1 Width at Half Height 0.6800 ms
AP 1 Width (Peak To Trough) 4.0700 ms
AP 1 Rate of Change Peak to Trough -22.5890 mV/ms
AP 1 AHP Depth 11.7798 mV
AP2 Amplitude 80.3455 mV
AP2 Width at Half Height 0.6800 ms
AP 2 Width (Peak to Trough) 4.0800 ms
AP 2 Rate of Change Peak to Trough -22.5619 mV/ms
AP 2 AHP Depth 11.7072 mV
AP 1-2 Amplitude Change Percent 0.2348 %
AP 1-2 Half Width Change Percent 0.0000 %
AP 1-2 Rate of Change Peak to Trough Percent Change -0.1196 %
AP 1-2 AHP Depth Percent Change -0.6158 %
Input Resistance 558.6240 MΩ
AP 1 Delay Mean 94.5100 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 184.0900 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 91.7750 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -25.0000 %
Steady State Accommodation Mean -50.0000 %
Accommodation Rate to Steady State -0.0386 %/ms
Accommodation at Steady State Mean -47.7639 %
Accommodation Rate Mean at Steady State 742.2802 ms
ISI CV 5.7583
ISI Median 136.9750 ms
ISI Burst Mean Change 4.9006 %
Spike Rate (Strong Stimulation) 15.0000 Hz
AP 1 Delay Mean (Strong Stimulation) 34.4600 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 68.2000 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 34.9050 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2088.7700 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 57.1131 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 10882.0 µm2
Number of Stems 10.0
Number of Bifurcations 72.0
Number of Branches 153.0
Overall Width 368.718 µm
Overall Height 489.192 µm
Overall Depth 253.02 µm
Average Diameter 0.68215 µm
Total Length 8012.57 µm
Total Surface 14756.1 µm2
Total Volume 5537.26 µm3
Max Euclidean Distance 443.745 µm
Max Path Distance 484.726 µm
Max Branch Order 10.0
Average Contraction 0.956508
Total Fragmentation 5000.0
Partition Asymmetry 0.509792
Average Rall's Ratio 1.43685
Average Bifurcation Angle Local 24.669 °
Average Bifurcation Angle Remote 62.9785 °
Fractal Dimension 1.0087
Complexity Summary
State Equations 4241
Optimal Time-Step 0.00791 ms
Relative Complexity 1048.32 HH
Model Size
Sections 156
Compartments 422
State Equations 4241
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00791 ms
Optimal Time-Step Error 0.04 %
Optimal Time-Step Benchmark Run Time 1048.32 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 0.55 %
Max. Stable Time-Step Benchmark Run Time 2073.62 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 15163 Hz
CVODE Steps Per AP 319
CVODE Benchmark Run Time 1001.31 HH
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