Layer 5 Continuous Accommodating Double Bouquet Cell (3)

Model Type:
Cell
Neurolex IDs: Double Bouquet Cell
Neocortex Layer 5
Keywords: continuous accommodating,Layer 5,GABAergic, inhibitory, neocortex, rat, somatosensory cortex, double bouquet
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000569
cACint209_L5_DBC_6a2bbf2a1b_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000569
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Delayed Regular Spikers (dRS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -69.06 mV
Rheobase Current Interval (0.01854, 0.02060] nA
Threshold Current Interval (0.46875, 0.52734] nA
Bias Current (to -80.00 mV) -0.0272 nA
Testing Temperature 34.0 °C
Stability Interval [-4.0625, 15.0] nA
AP 1-2 Amplitude Drop 0.1307 mV
AP 1 Steady State Amplitude Change 0.5733 mV
AP 1 Amplitude 74.4855 mV
AP 1 Width at Half Height 0.7100 ms
AP 1 Width (Peak To Trough) 4.7300 ms
AP 1 Rate of Change Peak to Trough -18.4471 mV/ms
AP 1 AHP Depth 12.7692 mV
AP2 Amplitude 74.3548 mV
AP2 Width at Half Height 0.7200 ms
AP 2 Width (Peak to Trough) 4.7200 ms
AP 2 Rate of Change Peak to Trough -18.4823 mV/ms
AP 2 AHP Depth 12.8815 mV
AP 1-2 Amplitude Change Percent -0.1754 %
AP 1-2 Half Width Change Percent 1.4085 %
AP 1-2 Rate of Change Peak to Trough Percent Change 0.1907 %
AP 1-2 AHP Depth Percent Change 0.8794 %
Input Resistance 438.5872 MΩ
AP 1 Delay Mean 118.6400 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 224.8700 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 108.0500 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean 0.0000 %
Steady State Accommodation Mean -33.3333 %
Accommodation Rate to Steady State -0.0264 %/ms
Accommodation at Steady State Mean -39.6704 %
Accommodation Rate Mean at Steady State 1042.0378 ms
ISI CV 7.8823
ISI Median 139.5000 ms
ISI Burst Mean Change 3.4265 %
Spike Rate (Strong Stimulation) 15.0000 Hz
AP 1 Delay Mean (Strong Stimulation) 43.6500 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 82.9900 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 40.2800 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2122.7800 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 73.9834 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 9840.66 µm2
Number of Stems 7.0
Number of Bifurcations 36.0
Number of Branches 78.0
Overall Width 320.399 µm
Overall Height 792.122 µm
Overall Depth 163.71 µm
Average Diameter 1.21329 µm
Total Length 5183.46 µm
Total Surface 18858.4 µm2
Total Volume 8197.65 µm3
Max Euclidean Distance 704.249 µm
Max Path Distance 711.886 µm
Max Branch Order 7.0
Average Contraction 0.970352
Total Fragmentation 1862.0
Partition Asymmetry 0.477888
Average Rall's Ratio 1.82983
Average Bifurcation Angle Local 22.5973 °
Average Bifurcation Angle Remote 42.2031 °
Fractal Dimension 1.00502
Complexity Summary
State Equations 2511
Optimal Time-Step 0.00787 ms
Relative Complexity 604.68 HH
Model Size
Sections 81
Compartments 249
State Equations 2511
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00787 ms
Optimal Time-Step Error 0.05 %
Optimal Time-Step Benchmark Run Time 604.68 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 0.52 %
Max. Stable Time-Step Benchmark Run Time 1189.19 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 14823 Hz
CVODE Steps Per AP 265
CVODE Benchmark Run Time 546.61 HH
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