Layer 5 Continuous Accommodating Chandelier Cell (5)

Model Type:
Cell
Neurolex IDs: Neocortex Layer 5
Chandelier Cell
Keywords: continuous accommodating,Layer 5,GABAergic, inhibitory, neocortex, rat, somatosensory cortex, chandelier, biophysical, continuous accommodating chandelier cell, Realistic Network, Neuron or other electrically excitable cell, Synapse, Spatio-temporal Activity Patterns, Detailed Neuronal Models
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000566
cACint209_L5_ChC_e98f63217d_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000566
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Delayed Regular Spikers (dRS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -69.19 mV
Rheobase Current Interval (0.01099, 0.01236] nA
Threshold Current Interval (0.29297, 0.35156] nA
Bias Current (to -80.00 mV) -0.0157 nA
Testing Temperature 34.0 °C
Stability Interval [-2.8125, 15.0] nA
AP 1-2 Amplitude Drop -0.3129 mV
AP 1 Steady State Amplitude Change 0.1674 mV
AP 1 Amplitude 75.9834 mV
AP 1 Width at Half Height 0.7200 ms
AP 1 Width (Peak To Trough) 4.2800 ms
AP 1 Rate of Change Peak to Trough -20.0289 mV/ms
AP 1 AHP Depth 9.7403 mV
AP2 Amplitude 76.2962 mV
AP2 Width at Half Height 0.7200 ms
AP 2 Width (Peak to Trough) 4.2800 ms
AP 2 Rate of Change Peak to Trough -20.0490 mV/ms
AP 2 AHP Depth 9.5137 mV
AP 1-2 Amplitude Change Percent 0.4118 %
AP 1-2 Half Width Change Percent 0.0000 %
AP 1-2 Rate of Change Peak to Trough Percent Change 0.1006 %
AP 1-2 AHP Depth Percent Change -2.3266 %
Input Resistance 716.0495 MΩ
AP 1 Delay Mean 143.2200 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 247.6100 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 106.4350 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean 0.0000 %
Steady State Accommodation Mean 0.0000 %
Accommodation Rate to Steady State 0.0000 %/ms
Accommodation at Steady State Mean -42.1453 %
Accommodation Rate Mean at Steady State 921.2604 ms
ISI CV 7.0161
ISI Median 143.8100 ms
ISI Burst Mean Change 3.9180 %
Spike Rate (Strong Stimulation) 15.5000 Hz
AP 1 Delay Mean (Strong Stimulation) 50.2000 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 86.3000 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 37.0800 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2183.0800 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 127.1884 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 5447.2 µm2
Number of Stems 3.0
Number of Bifurcations 49.0
Number of Branches 100.0
Overall Width 304.32 µm
Overall Height 596.793 µm
Overall Depth 205.27 µm
Average Diameter 0.861678 µm
Total Length 5140.99 µm
Total Surface 13295.6 µm2
Total Volume 4591.5 µm3
Max Euclidean Distance 351.255 µm
Max Path Distance 440.991 µm
Max Branch Order 11.0
Average Contraction 0.974905
Total Fragmentation 1289.0
Partition Asymmetry 0.464435
Average Rall's Ratio 1.64543
Average Bifurcation Angle Local 49.587 °
Average Bifurcation Angle Remote 52.4502 °
Fractal Dimension 1.00502
Complexity Summary
Relative Complexity 547.87 HH
State Equations 2541
Optimal Time-Step 0.00782 ms
Model Size
Sections 102
Compartments 252
State Equations 2541
Variable Time-Step Complexity
CVODE Steady State Step Frequency 15024 Hz
CVODE Steps Per AP 191
CVODE Benchmark Run Time 547.87 HH
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