Layer 5 Continuous Accommodating Bitufted Cell (3)

Model Type:
Cell
Neurolex IDs: Neocortex Layer 5
Keywords: continuous accommodating,Layer 5,Rat, somatosensory cortex, bitufted
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000559
cACint209_L5_BTC_6ab22ae2e0_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000559
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Delayed Regular Spikers (dRS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -69.20 mV
Rheobase Current Interval (0.01602, 0.01762] nA
Threshold Current Interval (0.35156, 0.41016] nA
Bias Current (to -80.00 mV) -0.0207 nA
Testing Temperature 34.0 °C
Stability Interval [-2.8125, 15.0] nA
AP 1-2 Amplitude Drop -0.2388 mV
AP 1 Steady State Amplitude Change 0.4614 mV
AP 1 Amplitude 81.1952 mV
AP 1 Width at Half Height 0.6200 ms
AP 1 Width (Peak To Trough) 2.7200 ms
AP 1 Rate of Change Peak to Trough -33.8696 mV/ms
AP 1 AHP Depth 10.9300 mV
AP2 Amplitude 81.4340 mV
AP2 Width at Half Height 0.6200 ms
AP 2 Width (Peak to Trough) 2.7200 ms
AP 2 Rate of Change Peak to Trough -33.8617 mV/ms
AP 2 AHP Depth 10.6699 mV
AP 1-2 Amplitude Change Percent 0.2941 %
AP 1-2 Half Width Change Percent -0.0000 %
AP 1-2 Rate of Change Peak to Trough Percent Change -0.0232 %
AP 1-2 AHP Depth Percent Change -2.3798 %
Input Resistance 571.0973 MΩ
AP 1 Delay Mean 125.1300 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 211.8600 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 88.0050 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean 0.0000 %
Steady State Accommodation Mean -25.0000 %
Accommodation Rate to Steady State -0.0192 %/ms
Accommodation at Steady State Mean -42.7515 %
Accommodation Rate Mean at Steady State 956.3473 ms
ISI CV 6.9946
ISI Median 119.5950 ms
ISI Burst Mean Change 2.9402 %
Spike Rate (Strong Stimulation) 18.0000 Hz
AP 1 Delay Mean (Strong Stimulation) 44.2300 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 73.9700 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 30.7100 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2142.9600 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 110.0046 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 7202.41 µm2
Number of Stems 3.0
Number of Bifurcations 66.0
Number of Branches 134.0
Overall Width 366.24 µm
Overall Height 670.727 µm
Overall Depth 377.65 µm
Average Diameter 0.762477 µm
Total Length 7886.16 µm
Total Surface 16484.2 µm2
Total Volume 4682.32 µm3
Max Euclidean Distance 505.695 µm
Max Path Distance 522.095 µm
Max Branch Order 11.0
Average Contraction 0.972123
Total Fragmentation 1523.0
Partition Asymmetry 0.562991
Average Rall's Ratio 1.941
Average Bifurcation Angle Local 40.7836 °
Average Bifurcation Angle Remote 57.9515 °
Fractal Dimension 1.00305
Complexity Summary
State Equations 4001
Optimal Time-Step 0.00785 ms
Relative Complexity 999.08 HH
Model Size
Sections 136
Compartments 398
State Equations 4001
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00785 ms
Optimal Time-Step Error 0.03 %
Optimal Time-Step Benchmark Run Time 999.08 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 0.52 %
Max. Stable Time-Step Benchmark Run Time 1959.45 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 14570 Hz
CVODE Steps Per AP 194
CVODE Benchmark Run Time 851.37 HH
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