Layer 4 Continuous Accommodating Nest Basket Cell (5)

Model Type:
Cell
Neurolex IDs: Neocortex basket cell
Neocortex Layer 4
Keywords: continuous accommodating,Layer 4,Fast-spiking, interneuron, GABAergic, inhibitory, neocortex, rat, somatosensory cortex, nest, basket
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000541
cACint209_L4_NBC_9060dda08b_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000541
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Delayed Regular Spikers (dRS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -70.97 mV
Rheobase Current Interval (0.01099, 0.01190] nA
Threshold Current Interval (0.17578, 0.23438] nA
Bias Current (to -80.00 mV) -0.0074 nA
Testing Temperature 34.0 °C
Stability Interval [-1.5625, 15.0] nA
AP 1-2 Amplitude Drop -0.0222 mV
AP 1 Steady State Amplitude Change 0.6676 mV
AP 1 Amplitude 82.8559 mV
AP 1 Width at Half Height 0.6400 ms
AP 1 Width (Peak To Trough) 3.1900 ms
AP 1 Rate of Change Peak to Trough -30.1885 mV/ms
AP 1 AHP Depth 13.4455 mV
AP2 Amplitude 82.8781 mV
AP2 Width at Half Height 0.6400 ms
AP 2 Width (Peak to Trough) 3.1400 ms
AP 2 Rate of Change Peak to Trough -30.6820 mV/ms
AP 2 AHP Depth 13.4633 mV
AP 1-2 Amplitude Change Percent 0.0268 %
AP 1-2 Half Width Change Percent 0.0000 %
AP 1-2 Rate of Change Peak to Trough Percent Change 1.6347 %
AP 1-2 AHP Depth Percent Change 0.1330 %
Input Resistance 1228.3929 MΩ
AP 1 Delay Mean 82.2700 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 156.5400 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 76.1550 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -25.0000 %
Steady State Accommodation Mean -25.0000 %
Accommodation Rate to Steady State -0.0199 %/ms
Accommodation at Steady State Mean -54.2191 %
Accommodation Rate Mean at Steady State 661.9718 ms
ISI CV 4.8356
ISI Median 127.7150 ms
ISI Burst Mean Change 5.0761 %
Spike Rate (Strong Stimulation) 16.5000 Hz
AP 1 Delay Mean (Strong Stimulation) 29.0100 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 56.1000 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 28.1150 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2115.1700 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 112.8188 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 5065.91 µm2
Number of Stems 9.0
Number of Bifurcations 17.0
Number of Branches 42.0
Overall Width 216.523 µm
Overall Height 385.125 µm
Overall Depth 133.18 µm
Average Diameter 0.873841 µm
Total Length 2786.71 µm
Total Surface 6485.79 µm2
Total Volume 2963.81 µm3
Max Euclidean Distance 260.97 µm
Max Path Distance 329.353 µm
Max Branch Order 4.0
Average Contraction 0.934885
Total Fragmentation 2173.0
Partition Asymmetry 0.476471
Average Rall's Ratio 0.579643
Average Bifurcation Angle Local 38.5779 °
Average Bifurcation Angle Remote 59.0467 °
Fractal Dimension 1.01183
Complexity Summary
State Equations 1451
Optimal Time-Step 0.00776 ms
Relative Complexity 344.94 HH
Model Size
Sections 43
Compartments 143
State Equations 1451
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00776 ms
Optimal Time-Step Error 0.10 %
Optimal Time-Step Benchmark Run Time 344.94 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 0.84 %
Max. Stable Time-Step Benchmark Run Time 669.36 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 14714 Hz
CVODE Steps Per AP 532
CVODE Benchmark Run Time 352.87 HH
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