Layer 4 Continuous Accommodating Nest Basket Cell (4)

Model Type:
Cell
Neurolex IDs: Neocortex basket cell
Neocortex Layer 4
Keywords: continuous accommodating,Layer 4,Fast-spiking, interneuron, GABAergic, inhibitory, neocortex, rat, somatosensory cortex, nest, basket
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000540
cACint209_L4_NBC_7b7132634e_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000540
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Delayed Regular Spikers (dRS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -71.16 mV
Rheobase Current Interval (0.01945, 0.02060] nA
Threshold Current Interval (0.23438, 0.29297] nA
Bias Current (to -80.00 mV) -0.0122 nA
Testing Temperature 34.0 °C
Stability Interval [-2.1875, 15.0] nA
AP 1-2 Amplitude Drop 0.0950 mV
AP 1 Steady State Amplitude Change 0.9027 mV
AP 1 Amplitude 86.0815 mV
AP 1 Width at Half Height 0.5700 ms
AP 1 Width (Peak To Trough) 2.3700 ms
AP 1 Rate of Change Peak to Trough -43.7205 mV/ms
AP 1 AHP Depth 17.5361 mV
AP2 Amplitude 85.9865 mV
AP2 Width at Half Height 0.5700 ms
AP 2 Width (Peak to Trough) 2.4100 ms
AP 2 Rate of Change Peak to Trough -43.0068 mV/ms
AP 2 AHP Depth 17.6598 mV
AP 1-2 Amplitude Change Percent -0.1104 %
AP 1-2 Half Width Change Percent 0.0000 %
AP 1-2 Rate of Change Peak to Trough Percent Change -1.6325 %
AP 1-2 AHP Depth Percent Change 0.7056 %
Input Resistance 733.4877 MΩ
AP 1 Delay Mean 81.5700 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 160.2500 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 80.2250 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -25.0000 %
Steady State Accommodation Mean -25.0000 %
Accommodation Rate to Steady State -0.0201 %/ms
Accommodation at Steady State Mean -52.3692 %
Accommodation Rate Mean at Steady State 885.5304 ms
ISI CV 5.1959
ISI Median 122.6850 ms
ISI Burst Mean Change 3.9273 %
Spike Rate (Strong Stimulation) 17.0000 Hz
AP 1 Delay Mean (Strong Stimulation) 27.9200 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 55.8700 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 28.8750 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2124.5800 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 71.3142 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 10324.5 µm2
Number of Stems 6.0
Number of Bifurcations 28.0
Number of Branches 61.0
Overall Width 329.622 µm
Overall Height 478.799 µm
Overall Depth 274.53 µm
Average Diameter 0.791079 µm
Total Length 4915.62 µm
Total Surface 10213.5 µm2
Total Volume 5141.25 µm3
Max Euclidean Distance 313.172 µm
Max Path Distance 347.868 µm
Max Branch Order 5.0
Average Contraction 0.955756
Total Fragmentation 3045.0
Partition Asymmetry 0.325
Average Rall's Ratio 0.619773
Average Bifurcation Angle Local 25.5896 °
Average Bifurcation Angle Remote 50.2138 °
Fractal Dimension 1.0085
Complexity Summary
State Equations 2541
Optimal Time-Step 0.00787 ms
Relative Complexity 605.87 HH
Model Size
Sections 62
Compartments 252
State Equations 2541
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00787 ms
Optimal Time-Step Error 0.10 %
Optimal Time-Step Benchmark Run Time 605.87 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 1.97 %
Max. Stable Time-Step Benchmark Run Time 1191.71 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 14648 Hz
CVODE Steps Per AP 413
CVODE Benchmark Run Time 588.70 HH
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