Layer 4 Continuous Accommodating Nest Basket Cell (2)

Model Type:
Cell
Neurolex IDs: Neocortex basket cell
Neocortex Layer 4
Keywords: continuous accommodating,Layer 4,Fast-spiking, interneuron, GABAergic, inhibitory, neocortex, rat, somatosensory cortex, nest, basket, biophysical, continuous accommodating nest basket cell, Realistic Network, Neuron or other electrically excitable cell, Synapse, Spatio-temporal Activity Patterns, Detailed Neuronal Models
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000538
cACint209_L4_NBC_3552e1f34a_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000538
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Delayed Regular Spikers (dRS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -71.92 mV
Rheobase Current Interval (0.01007, 0.01099] nA
Threshold Current Interval (0.17578, 0.23438] nA
Bias Current (to -80.00 mV) -0.0072 nA
Testing Temperature 34.0 °C
Stability Interval [-1.5625, 15.0] nA
AP 1-2 Amplitude Drop 0.3437 mV
AP 1 Steady State Amplitude Change 0.8533 mV
AP 1 Amplitude 80.0068 mV
AP 1 Width at Half Height 0.6700 ms
AP 1 Width (Peak To Trough) 5.0200 ms
AP 1 Rate of Change Peak to Trough -20.2033 mV/ms
AP 1 AHP Depth 21.4138 mV
AP2 Amplitude 79.6631 mV
AP2 Width at Half Height 0.6700 ms
AP 2 Width (Peak to Trough) 5.1500 ms
AP 2 Rate of Change Peak to Trough -19.6970 mV/ms
AP 2 AHP Depth 21.7764 mV
AP 1-2 Amplitude Change Percent -0.4296 %
AP 1-2 Half Width Change Percent 0.0000 %
AP 1-2 Rate of Change Peak to Trough Percent Change -2.5061 %
AP 1-2 AHP Depth Percent Change 1.6933 %
Input Resistance 1122.0620 MΩ
AP 1 Delay Mean 82.9900 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 191.0500 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 112.1700 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -33.3333 %
Steady State Accommodation Mean -33.3333 %
Accommodation Rate to Steady State -0.0254 %/ms
Accommodation at Steady State Mean -53.3626 %
Accommodation Rate Mean at Steady State 728.1112 ms
ISI CV 4.8147
ISI Median 180.1900 ms
ISI Burst Mean Change 7.6069 %
Spike Rate (Strong Stimulation) 11.0000 Hz
AP 1 Delay Mean (Strong Stimulation) 30.7300 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 75.3700 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 45.7950 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2111.3200 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 117.4714 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 4504.54 µm2
Number of Stems 10.0
Number of Bifurcations 18.0
Number of Branches 45.0
Overall Width 194.965 µm
Overall Height 453.777 µm
Overall Depth 139.71 µm
Average Diameter 0.783132 µm
Total Length 2610.74 µm
Total Surface 5744.11 µm2
Total Volume 2234.25 µm3
Max Euclidean Distance 280.864 µm
Max Path Distance 349.356 µm
Max Branch Order 5.0
Average Contraction 0.960893
Total Fragmentation 918.0
Partition Asymmetry 0.468519
Average Rall's Ratio 1.0825
Average Bifurcation Angle Local 35.1585 °
Average Bifurcation Angle Remote 66.0441 °
Fractal Dimension 1.0057
Complexity Summary
Relative Complexity 325.60 HH
State Equations 1341
Optimal Time-Step 0.00781 ms
Model Size
Sections 46
Compartments 132
State Equations 1341
Variable Time-Step Complexity
CVODE Steady State Step Frequency 15872 Hz
CVODE Steps Per AP 385
CVODE Benchmark Run Time 325.60 HH
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