Layer 4 Continuous Accommodating Martinotti Cell (5)

Model Type:
Cell
Neurolex IDs: Martinotti Cell
Neocortex Layer 4
Keywords: continuous accommodating,Layer 4,GABAergic, inhibitory, neocortex, rat, somatosensory cortex, Martinotti
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000536
cACint209_L4_MC_fa0d941a0b_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000536
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Delayed Regular Spikers (dRS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -68.31 mV
Rheobase Current Interval (0.02243, 0.02403] nA
Threshold Current Interval (0.35156, 0.41016] nA
Bias Current (to -80.00 mV) -0.0277 nA
Testing Temperature 34.0 °C
Stability Interval [-3.4375, 15.0] nA
AP 1-2 Amplitude Drop -2.3163 mV
AP 1 Steady State Amplitude Change -2.9028 mV
AP 1 Amplitude 61.5663 mV
AP 1 Width at Half Height 0.9600 ms
AP 1 Width (Peak To Trough) 4.5400 ms
AP 1 Rate of Change Peak to Trough -14.1621 mV/ms
AP 1 AHP Depth 2.7297 mV
AP2 Amplitude 63.8827 mV
AP2 Width at Half Height 0.8400 ms
AP 2 Width (Peak to Trough) 3.7900 ms
AP 2 Rate of Change Peak to Trough -17.9323 mV/ms
AP 2 AHP Depth 4.0806 mV
AP 1-2 Amplitude Change Percent 3.7624 %
AP 1-2 Half Width Change Percent -12.5000 %
AP 1-2 Rate of Change Peak to Trough Percent Change 26.6212 %
AP 1-2 AHP Depth Percent Change 49.4869 %
Input Resistance 481.9675 MΩ
AP 1 Delay Mean 93.0800 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 133.7500 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 36.6150 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -50.0000 %
Steady State Accommodation Mean -50.0000 %
Accommodation Rate to Steady State -0.0967 %/ms
Accommodation at Steady State Mean -82.6181 %
Accommodation Rate Mean at Steady State 186.0557 ms
ISI CV 2.9845
ISI Median 125.4000 ms
ISI Burst Mean Change -19.9410 %
Spike Rate (Strong Stimulation) 24.5000 Hz
AP 1 Delay Mean (Strong Stimulation) 38.5400 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 52.9600 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 14.5150 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2004.1200 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 118.8775 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 9072.13 µm2
Number of Stems 5.0
Number of Bifurcations 81.0
Number of Branches 166.0
Overall Width 493.729 µm
Overall Height 736.442 µm
Overall Depth 285.81 µm
Average Diameter 0.78348 µm
Total Length 9679.13 µm
Total Surface 19842.9 µm2
Total Volume 7102.46 µm3
Max Euclidean Distance 482.332 µm
Max Path Distance 664.321 µm
Max Branch Order 11.0
Average Contraction 0.940507
Total Fragmentation 4655.0
Partition Asymmetry 0.385514
Average Rall's Ratio 0.937027
Average Bifurcation Angle Local 12.8013 °
Average Bifurcation Angle Remote 39.0398 °
Fractal Dimension 1.01581
Complexity Summary
State Equations 4651
Optimal Time-Step 0.01013 ms
Relative Complexity 904.14 HH
Model Size
Sections 167
Compartments 463
State Equations 4651
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.01013 ms
Optimal Time-Step Error 2.30 %
Optimal Time-Step Benchmark Run Time 904.14 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 1.91 %
Max. Stable Time-Step Benchmark Run Time 2289.66 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 18245 Hz
CVODE Steps Per AP -18
CVODE Benchmark Run Time 1087.87 HH
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