Layer 4 Continuous Accommodating Large Basket Cell (5)

Model Type:
Cell
Neurolex IDs: Neocortex basket cell
Neocortex Layer 4
Keywords: continuous accommodating,Layer 4,Fast-spiking, interneuron, GABAergic, inhibitory, neocortex, rat, somatosensory cortex, large, basket
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000531
cACint209_L4_LBC_db543bcdea_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000531
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Delayed Regular Spikers (dRS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -69.27 mV
Rheobase Current Interval (0.01144, 0.01259] nA
Threshold Current Interval (0.23438, 0.29297] nA
Bias Current (to -80.00 mV) -0.0172 nA
Testing Temperature 34.0 °C
Stability Interval [-2.5, 15.0] nA
AP 1-2 Amplitude Drop 0.4287 mV
AP 1 Steady State Amplitude Change 0.7477 mV
AP 1 Amplitude 75.7071 mV
AP 1 Width at Half Height 0.7400 ms
AP 1 Width (Peak To Trough) 3.5100 ms
AP 1 Rate of Change Peak to Trough -23.2298 mV/ms
AP 1 AHP Depth 5.8295 mV
AP2 Amplitude 75.2785 mV
AP2 Width at Half Height 0.7300 ms
AP 2 Width (Peak to Trough) 3.5100 ms
AP 2 Rate of Change Peak to Trough -23.1805 mV/ms
AP 2 AHP Depth 6.0851 mV
AP 1-2 Amplitude Change Percent -0.5662 %
AP 1-2 Half Width Change Percent -1.3514 %
AP 1-2 Rate of Change Peak to Trough Percent Change -0.2122 %
AP 1-2 AHP Depth Percent Change 4.3855 %
Input Resistance 781.4687 MΩ
AP 1 Delay Mean 114.2500 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 175.3500 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 62.8400 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -40.0000 %
Steady State Accommodation Mean -40.0000 %
Accommodation Rate to Steady State -0.0394 %/ms
Accommodation at Steady State Mean -59.2166 %
Accommodation Rate Mean at Steady State 528.4076 ms
ISI CV 4.2927
ISI Median 118.2700 ms
ISI Burst Mean Change 5.6956 %
Spike Rate (Strong Stimulation) 17.5000 Hz
AP 1 Delay Mean (Strong Stimulation) 41.5400 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 64.4800 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 24.4200 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2106.1900 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 125.0747 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 4290.42 µm2
Number of Stems 7.0
Number of Bifurcations 34.0
Number of Branches 74.0
Overall Width 265.815 µm
Overall Height 671.301 µm
Overall Depth 219.68 µm
Average Diameter 0.769637 µm
Total Length 5196.2 µm
Total Surface 11594.4 µm2
Total Volume 3590.0 µm3
Max Euclidean Distance 453.785 µm
Max Path Distance 504.064 µm
Max Branch Order 10.0
Average Contraction 0.964032
Total Fragmentation 1538.0
Partition Asymmetry 0.522171
Average Rall's Ratio 0.839231
Average Bifurcation Angle Local 54.2577 °
Average Bifurcation Angle Remote 64.6111 °
Fractal Dimension 1.00687
Complexity Summary
State Equations 2591
Optimal Time-Step 0.00981 ms
Relative Complexity 483.25 HH
Model Size
Sections 75
Compartments 257
State Equations 2591
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00981 ms
Optimal Time-Step Error 0.50 %
Optimal Time-Step Benchmark Run Time 483.25 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 0.43 %
Max. Stable Time-Step Benchmark Run Time 1185.13 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 14639 Hz
CVODE Steps Per AP 230
CVODE Benchmark Run Time 528.05 HH
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