Layer 4 Continuous Accommodating Large Basket Cell (2)

Model Type:
Cell
Neurolex IDs: Neocortex basket cell
Neocortex Layer 4
Keywords: continuous accommodating,Layer 4,Fast-spiking, interneuron, GABAergic, inhibitory, neocortex, rat, somatosensory cortex, large, basket
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000528
cACint209_L4_LBC_66ec8fed8f_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000528
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Accommodating Wide AP Multi-Spikers (awMS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -68.94 mV
Rheobase Current Interval (0.01465, 0.01648] nA
Threshold Current Interval (0.41016, 0.46875] nA
Bias Current (to -80.00 mV) -0.0221 nA
Testing Temperature 34.0 °C
Stability Interval [-4.0625, 15.0] nA
AP 1-2 Amplitude Drop 1.1420 mV
AP 1 Steady State Amplitude Change 1.3756 mV
AP 1 Amplitude 68.4968 mV
AP 1 Width at Half Height 0.8800 ms
AP 1 Width (Peak To Trough) 6.0300 ms
AP 1 Rate of Change Peak to Trough -11.6775 mV/ms
AP 1 AHP Depth 1.9183 mV
AP2 Amplitude 67.3548 mV
AP2 Width at Half Height 0.8800 ms
AP 2 Width (Peak to Trough) 17.6100 ms
AP 2 Rate of Change Peak to Trough -3.9645 mV/ms
AP 2 AHP Depth 2.4608 mV
AP 1-2 Amplitude Change Percent -1.6672 %
AP 1-2 Half Width Change Percent -0.0000 %
AP 1-2 Rate of Change Peak to Trough Percent Change -66.0496 %
AP 1-2 AHP Depth Percent Change 28.2845 %
Input Resistance 556.2981 MΩ
AP 1 Delay Mean 140.9400 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 169.2500 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 31.2200 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -42.8571 %
Steady State Accommodation Mean -42.8571 %
Accommodation Rate to Steady State -0.0675 %/ms
Accommodation at Steady State Mean -80.6766 %
Accommodation Rate Mean at Steady State 275.2648 ms
ISI CV 3.0224
ISI Median 98.5900 ms
ISI Burst Mean Change 20.5581 %
Spike Rate (Strong Stimulation) 19.0000 Hz
AP 1 Delay Mean (Strong Stimulation) 52.3300 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 66.7200 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 16.8000 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2127.6500 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 99.9713 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 7239.74 µm2
Number of Stems 8.0
Number of Bifurcations 50.0
Number of Branches 107.0
Overall Width 408.389 µm
Overall Height 622.095 µm
Overall Depth 286.37 µm
Average Diameter 0.783804 µm
Total Length 7566.87 µm
Total Surface 18372.7 µm2
Total Volume 6205.77 µm3
Max Euclidean Distance 444.201 µm
Max Path Distance 471.287 µm
Max Branch Order 7.0
Average Contraction 0.96635
Total Fragmentation 2246.0
Partition Asymmetry 0.443243
Average Rall's Ratio 1.31341
Average Bifurcation Angle Local 35.5077 °
Average Bifurcation Angle Remote 45.6845 °
Fractal Dimension 1.00585
Complexity Summary
State Equations 3661
Optimal Time-Step 0.00815 ms
Relative Complexity 842.58 HH
Model Size
Sections 108
Compartments 364
State Equations 3661
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00815 ms
Optimal Time-Step Error 0.88 %
Optimal Time-Step Benchmark Run Time 842.58 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 1.53 %
Max. Stable Time-Step Benchmark Run Time 1715.51 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 14393 Hz
CVODE Steps Per AP 100
CVODE Benchmark Run Time 694.64 HH
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