Layer 4 Continuous Accommodating Double Bouquet Cell (5)

Model Type:
Cell
Neurolex IDs: Double Bouquet Cell
Neocortex Layer 4
Keywords: continuous accommodating,Layer 4,GABAergic, inhibitory, neocortex, rat, somatosensory cortex, double bouquet
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000526
cACint209_L4_DBC_e8a6fe8924_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000526
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Delayed Regular Spikers (dRS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -70.74 mV
Rheobase Current Interval (0.02014, 0.02106] nA
Threshold Current Interval (0.17578, 0.23438] nA
Bias Current (to -80.00 mV) -0.0134 nA
Testing Temperature 34.0 °C
Stability Interval [-1.875, 15.0] nA
AP 1-2 Amplitude Drop -0.1699 mV
AP 1 Steady State Amplitude Change 0.5976 mV
AP 1 Amplitude 87.0598 mV
AP 1 Width at Half Height 0.5600 ms
AP 1 Width (Peak To Trough) 2.6200 ms
AP 1 Rate of Change Peak to Trough -41.3860 mV/ms
AP 1 AHP Depth 21.3714 mV
AP2 Amplitude 87.2297 mV
AP2 Width at Half Height 0.5600 ms
AP 2 Width (Peak to Trough) 2.6200 ms
AP 2 Rate of Change Peak to Trough -41.4477 mV/ms
AP 2 AHP Depth 21.3632 mV
AP 1-2 Amplitude Change Percent 0.1952 %
AP 1-2 Half Width Change Percent 0.0000 %
AP 1-2 Rate of Change Peak to Trough Percent Change 0.1492 %
AP 1-2 AHP Depth Percent Change -0.0384 %
Input Resistance 690.3485 MΩ
AP 1 Delay Mean 76.2400 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 145.0300 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 70.6750 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -40.0000 %
Steady State Accommodation Mean -60.0000 %
Accommodation Rate to Steady State -0.0466 %/ms
Accommodation at Steady State Mean -64.3722 %
Accommodation Rate Mean at Steady State 713.7665 ms
ISI CV 3.7168
ISI Median 134.3000 ms
ISI Burst Mean Change 5.4804 %
Spike Rate (Strong Stimulation) 15.0000 Hz
AP 1 Delay Mean (Strong Stimulation) 23.1000 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 47.6500 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 25.0450 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2116.2000 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 78.5527 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 11222.4 µm2
Number of Stems 4.0
Number of Bifurcations 30.0
Number of Branches 63.0
Overall Width 217.195 µm
Overall Height 782.132 µm
Overall Depth 82.86 µm
Average Diameter 0.914275 µm
Total Length 3409.18 µm
Total Surface 10242.3 µm2
Total Volume 6799.67 µm3
Max Euclidean Distance 611.408 µm
Max Path Distance 678.105 µm
Max Branch Order 6.0
Average Contraction 0.913296
Total Fragmentation 3461.0
Partition Asymmetry 0.406111
Average Rall's Ratio 0.4202
Average Bifurcation Angle Local 39.0203 °
Average Bifurcation Angle Remote 66.8346 °
Fractal Dimension 1.01881
Complexity Summary
State Equations 1801
Optimal Time-Step 0.00791 ms
Relative Complexity 411.92 HH
Model Size
Sections 64
Compartments 178
State Equations 1801
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00791 ms
Optimal Time-Step Error 0.36 %
Optimal Time-Step Benchmark Run Time 411.92 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 1.22 %
Max. Stable Time-Step Benchmark Run Time 814.30 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 14729 Hz
CVODE Steps Per AP 409
CVODE Benchmark Run Time 403.26 HH
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