Layer 4 Continuous Accommodating Double Bouquet Cell (3)

Model Type:
Cell
Neurolex IDs: Double Bouquet Cell
Neocortex Layer 4
Keywords: continuous accommodating,Layer 4,GABAergic, inhibitory, neocortex, rat, somatosensory cortex, double bouquet, biophysical, continuous accommodating double bouquet cell, Realistic Network, Neuron or other electrically excitable cell, Synapse, Spatio-temporal Activity Patterns, Detailed Neuronal Models
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000524
cACint209_L4_DBC_a7aa7154d8_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000524
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Delayed Regular Spikers (dRS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -69.07 mV
Rheobase Current Interval (0.01305, 0.01373] nA
Threshold Current Interval (0.11719, 0.17578] nA
Bias Current (to -80.00 mV) -0.0148 nA
Testing Temperature 34.0 °C
Stability Interval [-1.5625, 15.0] nA
AP 1-2 Amplitude Drop 0.4791 mV
AP 1 Steady State Amplitude Change 0.5974 mV
AP 1 Amplitude 89.3751 mV
AP 1 Width at Half Height 0.5600 ms
AP 1 Width (Peak To Trough) 2.2600 ms
AP 1 Rate of Change Peak to Trough -46.6216 mV/ms
AP 1 AHP Depth 15.9898 mV
AP2 Amplitude 88.8960 mV
AP2 Width at Half Height 0.5600 ms
AP 2 Width (Peak to Trough) 2.2700 ms
AP 2 Rate of Change Peak to Trough -46.3173 mV/ms
AP 2 AHP Depth 16.2443 mV
AP 1-2 Amplitude Change Percent -0.5360 %
AP 1-2 Half Width Change Percent 0.0000 %
AP 1-2 Rate of Change Peak to Trough Percent Change -0.6528 %
AP 1-2 AHP Depth Percent Change 1.5916 %
Input Resistance 762.3985 MΩ
AP 1 Delay Mean 78.2800 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 150.5200 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 73.9550 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -20.0000 %
Steady State Accommodation Mean -60.0000 %
Accommodation Rate to Steady State -0.0503 %/ms
Accommodation at Steady State Mean -55.2568 %
Accommodation Rate Mean at Steady State 777.4102 ms
ISI CV 4.7548
ISI Median 119.8650 ms
ISI Burst Mean Change 4.7481 %
Spike Rate (Strong Stimulation) 17.0000 Hz
AP 1 Delay Mean (Strong Stimulation) 25.8500 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 51.6600 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 26.5000 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2104.3000 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 79.4052 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 5696.29 µm2
Number of Stems 3.0
Number of Bifurcations 31.0
Number of Branches 64.0
Overall Width 217.896 µm
Overall Height 839.402 µm
Overall Depth 119.89 µm
Average Diameter 0.943876 µm
Total Length 3107.93 µm
Total Surface 8962.79 µm2
Total Volume 3791.52 µm3
Max Euclidean Distance 634.729 µm
Max Path Distance 686.641 µm
Max Branch Order 7.0
Average Contraction 0.957326
Total Fragmentation 1289.0
Partition Asymmetry 0.617122
Average Rall's Ratio 1.174
Average Bifurcation Angle Local 43.5213 °
Average Bifurcation Angle Remote 67.8517 °
Fractal Dimension 1.00538
Complexity Summary
Relative Complexity 373.05 HH
State Equations 1671
Optimal Time-Step 0.00763 ms
Model Size
Sections 65
Compartments 165
State Equations 1671
Variable Time-Step Complexity
CVODE Steady State Step Frequency 14366 Hz
CVODE Steps Per AP 395
CVODE Benchmark Run Time 373.05 HH
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