Layer 4 Continuous Accommodating Double Bouquet Cell (2)

Model Type:
Cell
Neurolex IDs: Double Bouquet Cell
Neocortex Layer 4
Keywords: continuous accommodating,Layer 4,GABAergic, inhibitory, neocortex, rat, somatosensory cortex, double bouquet
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000523
cACint209_L4_DBC_78b422a17a_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000523
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Delayed Regular Spikers (dRS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -71.69 mV
Rheobase Current Interval (0.01717, 0.01831] nA
Threshold Current Interval (0.23438, 0.29297] nA
Bias Current (to -80.00 mV) -0.0090 nA
Testing Temperature 34.0 °C
Stability Interval [-1.875, 15.0] nA
AP 1-2 Amplitude Drop 0.3501 mV
AP 1 Steady State Amplitude Change 0.7599 mV
AP 1 Amplitude 85.6291 mV
AP 1 Width at Half Height 0.5900 ms
AP 1 Width (Peak To Trough) 3.8000 ms
AP 1 Rate of Change Peak to Trough -26.3728 mV/ms
AP 1 AHP Depth 14.5877 mV
AP2 Amplitude 85.2790 mV
AP2 Width at Half Height 0.6000 ms
AP 2 Width (Peak to Trough) 3.7900 ms
AP 2 Rate of Change Peak to Trough -26.4098 mV/ms
AP 2 AHP Depth 14.8141 mV
AP 1-2 Amplitude Change Percent -0.4089 %
AP 1-2 Half Width Change Percent 1.6949 %
AP 1-2 Rate of Change Peak to Trough Percent Change 0.1402 %
AP 1-2 AHP Depth Percent Change 1.5525 %
Input Resistance 921.8776 MΩ
AP 1 Delay Mean 67.2400 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 141.1000 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 75.3850 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -20.0000 %
Steady State Accommodation Mean -40.0000 %
Accommodation Rate to Steady State -0.0340 %/ms
Accommodation at Steady State Mean -52.8237 %
Accommodation Rate Mean at Steady State 751.2544 ms
ISI CV 5.0524
ISI Median 121.2700 ms
ISI Burst Mean Change 4.1294 %
Spike Rate (Strong Stimulation) 17.0000 Hz
AP 1 Delay Mean (Strong Stimulation) 23.9700 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 52.3500 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 29.3700 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2098.4700 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 70.2815 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 7858.86 µm2
Number of Stems 4.0
Number of Bifurcations 41.0
Number of Branches 85.0
Overall Width 255.929 µm
Overall Height 406.285 µm
Overall Depth 94.31 µm
Average Diameter 0.89558 µm
Total Length 2971.35 µm
Total Surface 7779.15 µm2
Total Volume 3951.16 µm3
Max Euclidean Distance 268.551 µm
Max Path Distance 297.602 µm
Max Branch Order 9.0
Average Contraction 0.954642
Total Fragmentation 1032.0
Partition Asymmetry 0.495599
Average Rall's Ratio 0.776667
Average Bifurcation Angle Local 50.8498 °
Average Bifurcation Angle Remote 66.3818 °
Fractal Dimension 1.00575
Complexity Summary
State Equations 1641
Optimal Time-Step 0.00761 ms
Relative Complexity 412.16 HH
Model Size
Sections 86
Compartments 162
State Equations 1641
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00761 ms
Optimal Time-Step Error 0.10 %
Optimal Time-Step Benchmark Run Time 412.16 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 1.12 %
Max. Stable Time-Step Benchmark Run Time 784.08 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 14658 Hz
CVODE Steps Per AP 465
CVODE Benchmark Run Time 398.26 HH
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