Layer 4 Continuous Accommodating Bipolar Cell (4)

Model Type:
Cell
Neurolex IDs: Bipolar Cell
Neocortex Layer 4
Keywords: continuous accommodating,Layer 4,GABAergic, inhibitory, neocortex, rat, somatosensory cortex, bipolar
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000510
cACint209_L4_BP_c99c259f39_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000510
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Delayed Regular Spikers (dRS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -70.78 mV
Rheobase Current Interval (0.00572, 0.00595] nA
Threshold Current Interval (0.00000, 0.05859] nA
Bias Current (to -80.00 mV) -0.0044 nA
Testing Temperature 34.0 °C
Stability Interval [-0.3125, 15.0] nA
AP 1-2 Amplitude Drop 0.6094 mV
AP 1 Steady State Amplitude Change 0.6743 mV
AP 1 Amplitude 97.2321 mV
AP 1 Width at Half Height 0.5100 ms
AP 1 Width (Peak To Trough) 1.9500 ms
AP 1 Rate of Change Peak to Trough -62.4167 mV/ms
AP 1 AHP Depth 24.4804 mV
AP2 Amplitude 96.6227 mV
AP2 Width at Half Height 0.5200 ms
AP 2 Width (Peak to Trough) 1.9300 ms
AP 2 Rate of Change Peak to Trough -62.8320 mV/ms
AP 2 AHP Depth 24.6431 mV
AP 1-2 Amplitude Change Percent -0.6268 %
AP 1-2 Half Width Change Percent 1.9608 %
AP 1-2 Rate of Change Peak to Trough Percent Change 0.6655 %
AP 1-2 AHP Depth Percent Change 0.6647 %
Input Resistance 2048.3881 MΩ
AP 1 Delay Mean 41.6400 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 87.8000 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 50.2600 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -60.0000 %
Steady State Accommodation Mean -60.0000 %
Accommodation Rate to Steady State -0.0658 %/ms
Accommodation at Steady State Mean -85.4064 %
Accommodation Rate Mean at Steady State 342.6015 ms
ISI CV 2.4715
ISI Median 201.8800 ms
ISI Burst Mean Change 17.7643 %
Spike Rate (Strong Stimulation) 11.0000 Hz
AP 1 Delay Mean (Strong Stimulation) 9.3400 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 27.8500 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 19.6800 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2085.4000 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 118.6048 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 2094.2 µm2
Number of Stems 2.0
Number of Bifurcations 7.0
Number of Branches 15.0
Overall Width 61.4086 µm
Overall Height 735.811 µm
Overall Depth 39.29 µm
Average Diameter 1.07428 µm
Total Length 1089.43 µm
Total Surface 2238.06 µm2
Total Volume 840.991 µm3
Max Euclidean Distance 764.131 µm
Max Path Distance 777.004 µm
Max Branch Order 6.0
Average Contraction 0.990942
Total Fragmentation 256.0
Partition Asymmetry 0.857143
Average Rall's Ratio 1.51667
Average Bifurcation Angle Local 47.5435 °
Average Bifurcation Angle Remote 44.3938 °
Fractal Dimension 1.00194
Complexity Summary
State Equations 541
Optimal Time-Step 0.00536 ms
Relative Complexity 188.81 HH
Model Size
Sections 16
Compartments 52
State Equations 541
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00536 ms
Optimal Time-Step Error 0.06 %
Optimal Time-Step Benchmark Run Time 188.81 HH
 
Maximum Stable Time-Step 0.03125 ms
Maximum Stable Time-Step Error 0.39 %
Max. Stable Time-Step Benchmark Run Time 505.98 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 15028 Hz
CVODE Steps Per AP 379
CVODE Benchmark Run Time 125.25 HH
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