Layer 4 Continuous Accommodating Bipolar Cell (2)

Model Type:
Cell
Neurolex IDs: Bipolar Cell
Neocortex Layer 4
Keywords: continuous accommodating,Layer 4,GABAergic, inhibitory, neocortex, rat, somatosensory cortex, bipolar
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000508
cACint209_L4_BP_a436dc77d5_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000508
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Delayed Regular Spikers (dRS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -70.81 mV
Rheobase Current Interval (0.00572, 0.00595] nA
Threshold Current Interval (0.00000, 0.05859] nA
Bias Current (to -80.00 mV) -0.0044 nA
Testing Temperature 34.0 °C
Stability Interval [-0.3125, 15.0] nA
AP 1-2 Amplitude Drop 0.0182 mV
AP 1 Steady State Amplitude Change 0.5161 mV
AP 1 Amplitude 96.8522 mV
AP 1 Width at Half Height 0.5300 ms
AP 1 Width (Peak To Trough) 1.8200 ms
AP 1 Rate of Change Peak to Trough -66.6089 mV/ms
AP 1 AHP Depth 24.3759 mV
AP2 Amplitude 96.8340 mV
AP2 Width at Half Height 0.5100 ms
AP 2 Width (Peak to Trough) 1.8100 ms
AP 2 Rate of Change Peak to Trough -67.1408 mV/ms
AP 2 AHP Depth 24.6909 mV
AP 1-2 Amplitude Change Percent -0.0187 %
AP 1-2 Half Width Change Percent -3.7736 %
AP 1-2 Rate of Change Peak to Trough Percent Change 0.7987 %
AP 1-2 AHP Depth Percent Change 1.2921 %
Input Resistance 2056.3734 MΩ
AP 1 Delay Mean 43.0200 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 90.8300 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 51.8550 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -60.0000 %
Steady State Accommodation Mean -60.0000 %
Accommodation Rate to Steady State -0.0670 %/ms
Accommodation at Steady State Mean -84.2755 %
Accommodation Rate Mean at Steady State 354.1997 ms
ISI CV 2.5045
ISI Median 197.5850 ms
ISI Burst Mean Change 16.9211 %
Spike Rate (Strong Stimulation) 11.5000 Hz
AP 1 Delay Mean (Strong Stimulation) 10.2000 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 29.3700 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 20.2700 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2088.6900 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 117.8123 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 2094.2 µm2
Number of Stems 2.0
Number of Bifurcations 7.0
Number of Branches 15.0
Overall Width 55.7812 µm
Overall Height 738.221 µm
Overall Depth 64.36 µm
Average Diameter 1.07428 µm
Total Length 1098.84 µm
Total Surface 2259.69 µm2
Total Volume 842.442 µm3
Max Euclidean Distance 766.78 µm
Max Path Distance 779.424 µm
Max Branch Order 6.0
Average Contraction 0.990242
Total Fragmentation 256.0
Partition Asymmetry 0.857143
Average Rall's Ratio 1.51667
Average Bifurcation Angle Local 51.3509 °
Average Bifurcation Angle Remote 46.6736 °
Fractal Dimension 1.00203
Complexity Summary
State Equations 581
Optimal Time-Step 0.00551 ms
Relative Complexity 195.62 HH
Model Size
Sections 16
Compartments 56
State Equations 581
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00551 ms
Optimal Time-Step Error 0.04 %
Optimal Time-Step Benchmark Run Time 195.62 HH
 
Maximum Stable Time-Step 0.03125 ms
Maximum Stable Time-Step Error 0.21 %
Max. Stable Time-Step Benchmark Run Time 539.20 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 15165 Hz
CVODE Steps Per AP 419
CVODE Benchmark Run Time 137.26 HH
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